ID CHS1_EXOEX Reviewed; 189 AA. AC P30590; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 14-DEC-2022, entry version 75. DE RecName: Full=Chitin synthase 1; DE EC=2.4.1.16; DE AltName: Full=Chitin-UDP acetyl-glucosaminyl transferase 1; DE Flags: Fragment; GN Name=CHS1; OS Exophiala exophialae (Black yeast-like fungus) (Phaeococcomyces OS exophialae). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala. OX NCBI_TaxID=13202; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=1731323; DOI=10.1073/pnas.89.2.519; RA Bowen A.R., Chen-Wu J.L.-P., Momany M., Young R., Szaniszlo P.J., RA Robbins P.W.; RT "Classification of fungal chitin synthases."; RL Proc. Natl. Acad. Sci. U.S.A. 89:519-523(1992). CC -!- FUNCTION: Polymerizes chitin, a structural polymer of the cell wall and CC septum, by transferring the sugar moiety of UDP-GlcNAc to the non- CC reducing end of the growing chitin polymer. {ECO:0000305}. CC -!- CATALYTIC ACTIVITY: CC Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha- CC D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + CC UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705, CC ChEBI:CHEBI:58223; EC=2.4.1.16; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the chitin synthase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M82952; AAA33634.1; -; Genomic_DNA. DR PIR; F38192; F38192. DR AlphaFoldDB; P30590; -. DR CAZy; GT2; Glycosyltransferase Family 2. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004100; F:chitin synthase activity; IEA:UniProtKB-EC. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0006031; P:chitin biosynthetic process; IEA:InterPro. DR InterPro; IPR004835; Chitin_synth. DR InterPro; IPR004834; Chitin_synth_fun. DR PANTHER; PTHR22914; CHITIN SYNTHASE; 1. DR Pfam; PF01644; Chitin_synth_1; 1. PE 3: Inferred from homology; KW Cell membrane; Cell wall biogenesis/degradation; Glycosyltransferase; KW Membrane; Transferase; Transmembrane. FT CHAIN <1..>189 FT /note="Chitin synthase 1" FT /id="PRO_0000193706" FT NON_TER 1 FT NON_TER 189 SQ SEQUENCE 189 AA; 21219 MW; 7383A678A708B22D CRC64; EFLFARTMIG VFKNIEYMCN RTSSKTWGKE AWKKIVVCIV SDGRAKINTR TRAVLAGLGV YQDGIAKQQV NGKDVTAHIY EYTTQVGLEL KGTQVSLKPR SATPVQLLFC LKEKNQKKIN SHRWFFQAFG RVLDPNICVL IDAGTKPGKD SIYQLWKAFD LEPMCGGACG EIKVMLDHGK KLYNPLIAT //