ID   T4S1_HUMAN              Reviewed;         202 AA.
AC   P30408; Q6IB51;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   04-NOV-2008, entry version 70.
DE   RecName: Full=Transmembrane 4 L6 family member 1;
DE   AltName: Full=Tumor-associated antigen L6;
DE   AltName: Full=Membrane component surface marker 1;
DE   AltName: Full=M3S1;
GN   Name=TM4SF1; Synonyms=M3S1, TAAL6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92228814; PubMed=1565644;
RA   Marken J.S., Schieven G.L., Hellstroem I., Hellstroem K.E., Aruffo A.;
RT   "Cloning and expression of the tumor-associated antigen L6.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:3503-3507(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TOPOLOGY.
RX   MEDLINE=94171760; PubMed=7510285;
RA   Marken J.S., Bajorath J., Edwards C.P., Farr A.G., Schieven G.L.,
RA   Hellstroem I., Hellstroem K.E., Aruffo A.;
RT   "Membrane topology of the L6 antigen and identification of the protein
RT   epitope recognized by the L6 monoclonal antibody.";
RL   J. Biol. Chem. 269:7397-7401(1994).
CC   -!- SUBUNIT: Present in high molecular weight complexes in tumor
CC       cells.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Highly expressed on lung, breast, colon, and
CC       ovarian carcinomas. It is also present on some normal cells,
CC       endothelial cells in particular.
CC   -!- SIMILARITY: Belongs to the L6 tetraspanin family.
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DR   EMBL; M90657; AAA36158.1; -; mRNA.
DR   EMBL; CR456953; CAG33234.1; -; mRNA.
DR   EMBL; BC008442; AAH08442.1; -; mRNA.
DR   EMBL; BC010166; AAH10166.1; -; mRNA.
DR   PIR; A42926; A42926.
DR   RefSeq; NP_055035.1; -.
DR   UniGene; Hs.351316; -.
DR   IntAct; P30408; -.
DR   Ensembl; ENSG00000169908; Homo sapiens.
DR   GeneID; 4071; -.
DR   KEGG; hsa:4071; -.
DR   H-InvDB; HIX0021987; -.
DR   HGNC; HGNC:11853; TM4SF1.
DR   HPA; CAB002760; -.
DR   HPA; HPA002823; -.
DR   MIM; 191155; gene.
DR   PharmGKB; PA36554; -.
DR   HOVERGEN; P30408; -.
DR   NextBio; 15960; -.
DR   ArrayExpress; P30408; -.
DR   CleanEx; HS_TM4SF1; -.
DR   GermOnline; ENSG00000169908; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
DR   InterPro; IPR008661; L6_membrane.
DR   Pfam; PF05805; L6_membrane; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Membrane; Transmembrane.
FT   CHAIN         1    202       Transmembrane 4 L6 family member 1.
FT                                /FTId=PRO_0000219295.
FT   TOPO_DOM      1      9       Cytoplasmic (Probable).
FT   TRANSMEM     10     30       Probable.
FT   TOPO_DOM     31     49       Extracellular (Probable).
FT   TRANSMEM     50     70       Probable.
FT   TOPO_DOM     71     93       Cytoplasmic (Probable).
FT   TRANSMEM     94    114       Probable.
FT   TOPO_DOM    115    161       Extracellular (Probable).
FT   TRANSMEM    162    182       Probable.
FT   TOPO_DOM    183    202       Cytoplasmic (Probable).
FT   CARBOHYD    129    129       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    159    159       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   202 AA;  21632 MW;  80D82C47902B8CD4 CRC64;
     MCYGKCARCI GHSLVGLALL CIAANILLYF PNGETKYASE NHLSRFVWFF SGIVGGGLLM
     LLPAFVFIGL EQDDCCGCCG HENCGKRCAM LSSVLAALIG IAGSGYCVIV AALGLAEGPL
     CLDSLGQWNY TFASTEGQYL LDTSTWSECT EPKHIVEWNV SLFSILLALG GIEFILCLIQ
     VINGVLGGIC GFCCSHQQQY DC
//