ID   T4S1_HUMAN              Reviewed;         202 AA.
AC   P30408; Q6IB51;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   29-APR-2015, entry version 116.
DE   RecName: Full=Transmembrane 4 L6 family member 1;
DE   AltName: Full=Membrane component chromosome 3 surface marker 1;
DE   AltName: Full=Tumor-associated antigen L6;
GN   Name=TM4SF1; Synonyms=M3S1, TAAL6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1565644; DOI=10.1073/pnas.89.8.3503;
RA   Marken J.S., Schieven G.L., Hellstroem I., Hellstroem K.E., Aruffo A.;
RT   "Cloning and expression of the tumor-associated antigen L6.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:3503-3507(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TOPOLOGY.
RX   PubMed=7510285;
RA   Marken J.S., Bajorath J., Edwards C.P., Farr A.G., Schieven G.L.,
RA   Hellstroem I., Hellstroem K.E., Aruffo A.;
RT   "Membrane topology of the L6 antigen and identification of the protein
RT   epitope recognized by the L6 monoclonal antibody.";
RL   J. Biol. Chem. 269:7397-7401(1994).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- SUBUNIT: Present in high molecular weight complexes in tumor
CC       cells.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Highly expressed in lung, breast, colon and
CC       ovarian carcinomas. It is also present on some normal cells,
CC       endothelial cells in particular.
CC   -!- SIMILARITY: Belongs to the L6 tetraspanin family. {ECO:0000305}.
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DR   EMBL; M90657; AAA36158.1; -; mRNA.
DR   EMBL; CR456953; CAG33234.1; -; mRNA.
DR   EMBL; BC008442; AAH08442.1; -; mRNA.
DR   EMBL; BC010166; AAH10166.1; -; mRNA.
DR   CCDS; CCDS3143.1; -.
DR   PIR; A42926; A42926.
DR   RefSeq; NP_055035.1; NM_014220.2.
DR   UniGene; Hs.351316; -.
DR   ProteinModelPortal; P30408; -.
DR   BioGrid; 110249; 6.
DR   IntAct; P30408; 5.
DR   MINT; MINT-1371524; -.
DR   STRING; 9606.ENSP00000304277; -.
DR   BioMuta; TM4SF1; -.
DR   DMDM; 267068; -.
DR   MaxQB; P30408; -.
DR   PaxDb; P30408; -.
DR   PRIDE; P30408; -.
DR   DNASU; 4071; -.
DR   Ensembl; ENST00000305366; ENSP00000304277; ENSG00000169908.
DR   GeneID; 4071; -.
DR   KEGG; hsa:4071; -.
DR   UCSC; uc003exb.1; human.
DR   CTD; 4071; -.
DR   GeneCards; GC03M149086; -.
DR   HGNC; HGNC:11853; TM4SF1.
DR   HPA; CAB002760; -.
DR   HPA; HPA002823; -.
DR   MIM; 191155; gene.
DR   neXtProt; NX_P30408; -.
DR   PharmGKB; PA36554; -.
DR   eggNOG; NOG126713; -.
DR   GeneTree; ENSGT00390000010992; -.
DR   HOGENOM; HOG000030899; -.
DR   HOVERGEN; HBG000076; -.
DR   InParanoid; P30408; -.
DR   OMA; IGHSLVW; -.
DR   OrthoDB; EOG7SN8DH; -.
DR   PhylomeDB; P30408; -.
DR   TreeFam; TF331371; -.
DR   ChiTaRS; TM4SF1; human.
DR   GeneWiki; TM4SF1; -.
DR   GenomeRNAi; 4071; -.
DR   NextBio; 15960; -.
DR   PRO; PR:P30408; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; P30408; -.
DR   CleanEx; HS_TM4SF1; -.
DR   ExpressionAtlas; P30408; baseline and differential.
DR   Genevestigator; P30408; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR   InterPro; IPR008661; L6_membrane.
DR   Pfam; PF05805; L6_membrane; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    202       Transmembrane 4 L6 family member 1.
FT                                /FTId=PRO_0000219295.
FT   TOPO_DOM      1      9       Cytoplasmic.
FT                                {ECO:0000305|PubMed:7510285}.
FT   TRANSMEM     10     30       Helical. {ECO:0000305}.
FT   TOPO_DOM     31     49       Extracellular.
FT                                {ECO:0000305|PubMed:7510285}.
FT   TRANSMEM     50     70       Helical. {ECO:0000305}.
FT   TOPO_DOM     71     93       Cytoplasmic.
FT                                {ECO:0000305|PubMed:7510285}.
FT   TRANSMEM     94    114       Helical. {ECO:0000305}.
FT   TOPO_DOM    115    161       Extracellular.
FT                                {ECO:0000305|PubMed:7510285}.
FT   TRANSMEM    162    182       Helical. {ECO:0000305}.
FT   TOPO_DOM    183    202       Cytoplasmic.
FT                                {ECO:0000305|PubMed:7510285}.
FT   CARBOHYD    129    129       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    159    159       N-linked (GlcNAc...). {ECO:0000255}.
SQ   SEQUENCE   202 AA;  21632 MW;  80D82C47902B8CD4 CRC64;
     MCYGKCARCI GHSLVGLALL CIAANILLYF PNGETKYASE NHLSRFVWFF SGIVGGGLLM
     LLPAFVFIGL EQDDCCGCCG HENCGKRCAM LSSVLAALIG IAGSGYCVIV AALGLAEGPL
     CLDSLGQWNY TFASTEGQYL LDTSTWSECT EPKHIVEWNV SLFSILLALG GIEFILCLIQ
     VINGVLGGIC GFCCSHQQQY DC
//