ID POLG_EC11G STANDARD; PRT; 1374 AA. AC P29813; DT 01-APR-1993 (REL. 25, CREATED) DT 01-APR-1993 (REL. 25, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE GENOME POLYPROTEIN (COAT PROTEIN VP1; CORE PROTEINS P2A TO P2C, P3A; DE GENOME-LINKED PROTEIN VPG; PICORNAIN 3C (EC 3.4.22.28) (PROTEASE 3C) DE (P3C); RNA-DIRECTED RNA POLYMERASE P3D (EC 2.7.7.48)) (FRAGMENT). OS ECHOVIRUS 11 (STRAIN GREGORY). OC VIRIDAE; SS-RNA NONENVELOPED VIRUSES; PICORNAVIRIDAE; ENTEROVIRUSES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 91011360. RA AUVINEN P., HYYPIAE T.; RL J. GEN. VIROL. 71:2133-2139(1990). CC -!- PTM: SPECIFIC ENZYMATIC CLEAVAGES IN VIVO YIELD MATURE PROTEINS. CC -!- SIMILARITY: THE PROTEASE BELONGS TO PEPTIDASE FAMILY C3. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D10582; G465395; -. DR PIR; A36642; GNNYEC. KW POLYPROTEIN; COAT PROTEIN; CORE PROTEIN; RNA-DIRECTED RNA POLYMERASE; KW HYDROLASE; THIOL PROTEASE. FT NON_TER 1 1 FT CHAIN <1 43 COAT PROTEIN VP1 (P1D). FT CHAIN 44 190 CORE PROTEIN P2A. FT CHAIN 191 289 CORE PROTEIN P2B. FT CHAIN 290 618 CORE PROTEIN P2C. FT CHAIN 619 707 CORE PROTEIN P3A. FT CHAIN 708 729 GENOME-LINKED PROTEIN VPG (P3B). FT CHAIN 730 912 PICORNAIN 3C. FT CHAIN 913 1374 RNA-DIRECTED RNA POLYMERASE P3D. FT ACT_SITE 876 876 PROTEASE (POTENTIAL). FT ACT_SITE 890 890 PROTEASE (POTENTIAL). SQ SEQUENCE 1374 AA; 154599 MW; 009BBAD6 CRC32; PSYANTKNAS TVNFTPTNVT DKRTSINYIP ETVKPDLSNY GAFGYQSGAV YVVNYRVVNR HLATHTDWQN CVWEDYNRDL LISTTTAHGC DVIARCRCST GVYYCQSKGK HYPVNFEGPG LVEVQESEYY PKRYQSHVLL AAGFSEPGDC GGILRCEHGV IGIVTMGGEG VVGFADVRDL LWLEDDAMEQ GVKDYVEQLG NAFGSGFTNQ ICEQVNLLKE SLVGQDSILE KSLKALVKII SALVIVVRNH DDLITVTATL ALIGCTSSPW RWLKQKVSQY YGIPMAERQN NGWLKKFTEM TNSCKGMEWI SIKIQKFIEW LKVKILPEVR EKHEFLNRLK QLPLLESQIA TIEQSAPSQS DQEQLFSNVQ YFAHYCRKYA PLYASEAKRV FSLEKKMSNY IQFKSKCRIE PVCLLLHGSP GAGKSVATNL IGRSLAEKLN SSVYTLPPDP DHFDGYKQQA VVIVDDLCQN PDGKDVSLFC QMVSSVDFVP PMAALEEKGI LFTSLFVLAS TNAGSINAPT VSDSRALARR FHFDMNIEVI SMYSQNGKIN MPMSEKTCDE ECCPVNFKRC CPLVCGKAIQ FIDRRTQVRY SLDMLVTEMF REYNHRHSVG ATLEALFQGP PIYREIKISV APETPPPPAI ADLLKSVDSE AVREYCKEKG WLVPEVNSTL QIEKHVSRAF ICLQALTTFV SVAGIIYIIY KLFAGFQGAY TGMPNQKPKV PTLRQAKVQG PAFEFAVAMM KRNSSTVKTE YREFTMLGIY DRWAVLPRHA KPGPTILMNN QEVGVLDAKE LVDKDGTNLE LTLLKLNRNE KFRDIRGFLA KEEVEANQAV LAINTSKFPN MYIPVGQVTD YGFLNLGGTP TKRMLMSNFP TRAGQCGGVL MSTGKVLGIH VGGNGHQGFS AALLKHYFND EQGEIEFIES SKDAGFPIIN TPSKTKLEPS VFHQVFEGDK EPAVLRNGDP RLKANFEEAI FSKYIGNVNT HVDEYMLEAV DHYAGQLATL DISTEPMRLE DAVYGTEGLE ALDLTTSAGY PYVALGIKKR DILSRRTRDL TKLKECMDKY GLNLPMVTYV KDELRSADKV AKGKSRLIEA SSLNDSVAMR QTFGNLYRTF HLNPGIVTGS AVGCDPDLFW SKIPVMLDGH LIAFDYSGYD ASLSPVWFAC LKLLLEKLGY THKETNYIDY LCNSHHLYRD KHYFERGGMP SGYSGTSMFN SMINNIIIRT LMLKVYKGID LDQFRMIAYG DDVIASYPWP IDASLLAETG KGYGLIMTPA DKGECFNEVT WTNVTFLKRY FRADEQYPFL VHPVMPMKDI HESIRWTKDP KNTQDHVRSL CLLAWHNGEH EYEEFIRKIR SVPVGRCLTL PAFSTLRRKW LDSF //