ID PTN4_HUMAN Reviewed; 926 AA. AC P29074; DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-1992, sequence version 1. DT 05-MAY-2009, entry version 91. DE RecName: Full=Tyrosine-protein phosphatase non-receptor type 4; DE EC=3.1.3.48; DE AltName: Full=Protein-tyrosine phosphatase MEG1; DE Short=PTPase-MEG1; DE Short=MEG; GN Name=PTPN4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=91288564; PubMed=1648233; DOI=10.1073/pnas.88.13.5867; RA Gu M., York J.D., Warshawsky I., Majerus P.W.; RT "Identification, cloning, and expression of a cytosolic megakaryocyte RT protein-tyrosine-phosphatase with sequence homology to cytoskeletal RT protein 4.1."; RL Proc. Natl. Acad. Sci. U.S.A. 88:5867-5871(1991). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Colon; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP STRUCTURE BY NMR OF 507-612. RG RIKEN structural genomics initiative (RSGI); RT "Solution structure of PDZ domain of protein tyrosine phosphatase, RT non-receptor type 4."; RL Submitted (NOV-2005) to the PDB data bank. CC -!- FUNCTION: May act at junctions between the membrane and the CC cytoskeleton. CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. CC -!- INTERACTION: CC P00519:ABL1; NbExp=1; IntAct=EBI-710431, EBI-375543; CC P06241:FYN; NbExp=1; IntAct=EBI-710431, EBI-515315; CC P62993:GRB2; NbExp=1; IntAct=EBI-710431, EBI-401755; CC Q92993:HTATIP; NbExp=1; IntAct=EBI-710431, EBI-399080; CC P16333:NCK1; NbExp=1; IntAct=EBI-710431, EBI-389883; CC P27986:PIK3R1; NbExp=1; IntAct=EBI-710431, EBI-79464; CC -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; CC Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By CC similarity). CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. CC Non-receptor class subfamily. CC -!- SIMILARITY: Contains 1 FERM domain. CC -!- SIMILARITY: Contains 1 PDZ (DHR) domain. CC -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M68941; AAA36530.1; -; mRNA. DR EMBL; BC010674; AAH10674.1; -; mRNA. DR IPI; IPI00019949; -. DR PIR; A41105; A41105. DR RefSeq; NP_002821.1; -. DR UniGene; Hs.469809; -. DR PDB; 2CS5; NMR; -; A=507-612. DR PDB; 2I75; X-ray; 2.45 A; A=610-926. DR PDB; 2VPH; X-ray; 1.90 A; A/B=513-610. DR PDBsum; 2CS5; -. DR PDBsum; 2I75; -. DR PDBsum; 2VPH; -. DR SMR; P29074; 638-913. DR IntAct; P29074; 11. DR PhosphoSite; P29074; -. DR PeptideAtlas; P29074; -. DR PRIDE; P29074; -. DR Ensembl; ENSG00000088179; Homo sapiens. DR GeneID; 5775; -. DR KEGG; hsa:5775; -. DR GeneCards; GC02P120233; -. DR H-InvDB; HIX0002413; -. DR HGNC; HGNC:9656; PTPN4. DR MIM; 176878; gene. DR PharmGKB; PA34000; -. DR HOGENOM; P29074; -. DR HOVERGEN; P29074; -. DR OMA; P29074; QVTCHSE. DR BRENDA; 3.1.3.48; 247. DR DrugBank; DB00630; Alendronate. DR LinkHub; P29074; -. DR NextBio; 22462; -. DR ArrayExpress; P29074; -. DR Bgee; P29074; -. DR CleanEx; HS_PTPN4; -. DR GO; GO:0005737; C:cytoplasm; TAS:ProtInc. DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro. DR GO; GO:0019898; C:extrinsic to membrane; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro. DR GO; GO:0004726; F:non-membrane spanning protein tyrosine phos...; TAS:ProtInc. DR GO; GO:0006470; P:protein amino acid dephosphorylation; TAS:ProtInc. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR019750; Band_41_sg. DR InterPro; IPR000798; Ez/rad/moesin. DR InterPro; IPR014847; FERM-adjacent. DR InterPro; IPR014352; FERM/acyl-CoA_bd_prot_3-hlx. DR InterPro; IPR019748; FERM_central. DR InterPro; IPR019747; FERM_CS. DR InterPro; IPR000299; FERM_dom. DR InterPro; IPR001478; PDZ/DHR/GLGF. DR InterPro; IPR011993; PH_type. DR InterPro; IPR000387; Tyr_Pase. DR InterPro; IPR016130; Tyr_Pase_AS. DR InterPro; IPR012151; Tyr_Pase_non-rcpt_typ-3/4. DR InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt. DR Gene3D; G3DSA:1.20.80.10; ACBP; 1. DR Gene3D; G3DSA:2.30.29.30; PH_type; 1. DR Pfam; PF08736; FA; 1. DR Pfam; PF00373; FERM_M; 1. DR Pfam; PF00595; PDZ; 1. DR Pfam; PF00102; Y_phosphatase; 1. DR PIRSF; PIRSF000927; Tyr-Ptase_nr3; 1. DR PRINTS; PR00935; BAND41. DR PRINTS; PR00661; ERMFAMILY. DR PRINTS; PR00700; PRTYPHPHTASE. DR SMART; SM00295; B41; 1. DR SMART; SM00228; PDZ; 1. DR SMART; SM00194; PTPc; 1. DR PROSITE; PS00660; FERM_1; 1. DR PROSITE; PS00661; FERM_2; 1. DR PROSITE; PS50057; FERM_3; 1. DR PROSITE; PS50106; PDZ; 1. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell membrane; Cytoplasm; Cytoskeleton; Hydrolase; KW Membrane; Protein phosphatase. FT CHAIN 1 926 Tyrosine-protein phosphatase non-receptor FT type 4. FT /FTId=PRO_0000219434. FT DOMAIN 29 312 FERM. FT DOMAIN 517 589 PDZ. FT DOMAIN 655 911 Tyrosine-protein phosphatase. FT ACT_SITE 852 852 Phosphocysteine intermediate (By FT similarity). FT STRAND 516 520 FT STRAND 530 535 FT HELIX 536 538 FT STRAND 540 547 FT HELIX 552 555 FT STRAND 556 558 FT STRAND 565 569 FT HELIX 579 587 FT HELIX 589 591 FT STRAND 596 602 FT HELIX 639 651 FT HELIX 654 661 FT TURN 677 679 FT HELIX 680 682 FT HELIX 692 694 FT STRAND 695 697 FT STRAND 704 713 FT STRAND 720 726 FT HELIX 731 733 FT HELIX 734 743 FT STRAND 748 751 FT STRAND 755 757 FT STRAND 773 776 FT STRAND 779 783 FT STRAND 790 801 FT TURN 802 805 FT STRAND 806 815 FT STRAND 820 823 FT HELIX 828 841 FT STRAND 848 851 FT STRAND 853 857 FT HELIX 858 873 FT HELIX 880 888 FT HELIX 898 911 SQ SEQUENCE 926 AA; 105911 MW; 4DAC6A87A675CFB0 CRC64; MTSRFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFKVNKHDQ GQVLLDVVFK HLDLTEQDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP YSLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILTGRLP CPSNTAALLA SFAVQSELGD YDQSENLSGY LSDYSFIPNQ PQDFEKEIAK LHQQHIGLSP AEAEFNYLNT ARTLELYGVE FHYARDQSNN EIMIGVMSGG ILIYKNRVRM NTFPWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKNLWKA CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN KDRVFARSPS KPLARKLMDW EVVSRNSISD DRLETQSLPS RSPPGTPNHR NSTFTQEGTR LRPSSVGHLV DHMVHTSPSE VFVNQRSPSS TQANSIVLES SPSQETPGDG KPPALPPKQS KKNSWNQIHY SHSQQDLESH INETFDIPSS PEKPTPNGGI PHDNLVLIRM KPDENGRFGF NVKGGYDQKM PVIVSRVAPG TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC ERHSGELMLL VRPNAVYDVV EEKLENEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL ITGTVLTQFD QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG NEDYINANYI NMEIPSSSII NQYIACQGPL PHTCTDFWQM TWEQGSSMVV MLTTQVERGR VKCHQYWPEP TGSSSYGCYQ VTCHSEEGNT AYIFRKMTLF NQEKNESRPL TQIQYIAWPD HGVPDDSSDF LDFVCHVRNK RAGKEEPVVV HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ YRFVCEAILK VYEEGFVKPL TTSTNK //