ID PTN4_HUMAN STANDARD; PRT; 926 AA. AC P29074; DT 01-DEC-1992 (REL. 24, CREATED) DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE PROTEIN-TYROSINE PHOSPHATASE MEG1 (EC 3.1.3.48) (PTPASE-MEG1) (MEG). GN PTPN4. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC PRIMATES; CATARRHINI; HOMINIDAE; HOMO. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 91288564. RA GU M., YORK J.D., WARSHAWSKY I., MAJERUS P.W.; RT "Identification, cloning, and expression of a cytosolic megakaryocyte RT protein-tyrosine-phosphatase with sequence homology to cytoskeletal RT protein 4.1."; RL PROC. NATL. ACAD. SCI. U.S.A. 88:5867-5871(1991). CC -!- FUNCTION: MAY ACT AT JUNCTIONS BETWEEN THE MEMBRANE AND THE CC CYTOSKELETON. CC -!- CATALYTIC ACTIVITY: PROTEIN TYROSINE PHOSPHATE + H(2)O = CC PROTEIN TYROSINE + ORTHOPHOSPHATE. CC -!- SIMILARITY: CONTAINS A DOMAIN FOUND IN BAND 4.1, EZRIN, MOESIN, CC RADIXIN, AND TALIN. CC -!- SIMILARITY: BELONGS TO THE NON-RECEPTOR CLASS OF THE PROTEIN- CC TYROSINE PHOSPHATASE FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M68941; G190748; -. DR PIR; A41105; A41105. DR MIM; 176878; -. DR PROSITE; PS00660; BAND_41_1; 1. DR PROSITE; PS00661; BAND_41_2; 1. DR PROSITE; PS50057; BAND_41_3; 1. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1. DR PFAM; PF00102; Y_phosphatase; 1. DR PFAM; PF00373; Band_41; 1. DR PFAM; PF00595; PDZ; 1. DR HSSP; P18052; 1YFO. KW STRUCTURAL PROTEIN; CYTOSKELETON; HYDROLASE. FT DOMAIN 84 241 BAND 4.1-LIKE DOMAIN. FT DOMAIN 677 926 PROTEIN-TYROSINE PHOSPHATASE. FT ACT_SITE 852 852 BY SIMILARITY. SQ SEQUENCE 926 AA; 105911 MW; AE4F2DAE CRC32; MTSRFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFKVNKHDQ GQVLLDVVFK HLDLTEQDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP YSLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILTGRLP CPSNTAALLA SFAVQSELGD YDQSENLSGY LSDYSFIPNQ PQDFEKEIAK LHQQHIGLSP AEAEFNYLNT ARTLELYGVE FHYARDQSNN EIMIGVMSGG ILIYKNRVRM NTFPWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKNLWKA CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN KDRVFARSPS KPLARKLMDW EVVSRNSISD DRLETQSLPS RSPPGTPNHR NSTFTQEGTR LRPSSVGHLV DHMVHTSPSE VFVNQRSPSS TQANSIVLES SPSQETPGDG KPPALPPKQS KKNSWNQIHY SHSQQDLESH INETFDIPSS PEKPTPNGGI PHDNLVLIRM KPDENGRFGF NVKGGYDQKM PVIVSRVAPG TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC ERHSGELMLL VRPNAVYDVV EEKLENEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL ITGTVLTQFD QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG NEDYINANYI NMEIPSSSII NQYIACQGPL PHTCTDFWQM TWEQGSSMVV MLTTQVERGR VKCHQYWPEP TGSSSYGCYQ VTCHSEEGNT AYIFRKMTLF NQEKNESRPL TQIQYIAWPD HGVPDDSSDF LDFVCHVRNK RAGKEEPVVV HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ YRFVCEAILK VYEEGFVKPL TTSTNK //