ID PTN4_HUMAN Reviewed; 926 AA. AC P29074; DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-1992, sequence version 1. DT 31-OCT-2006, entry version 67. DE Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) DE (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG). GN Name=PTPN4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=91288564; PubMed=1648233; RA Gu M., York J.D., Warshawsky I., Majerus P.W.; RT "Identification, cloning, and expression of a cytosolic megakaryocyte RT protein-tyrosine-phosphatase with sequence homology to cytoskeletal RT protein 4.1."; RL Proc. Natl. Acad. Sci. U.S.A. 88:5867-5871(1991). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Colon; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May act at junctions between the membrane and the CC cytoskeleton. CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. CC -!- INTERACTION: CC Q92993:HTATIP; NbExp=1; IntAct=EBI-710431, EBI-399080; CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. CC Non-receptor class subfamily. CC -!- SIMILARITY: Contains 1 FERM domain. CC -!- SIMILARITY: Contains 1 PDZ (DHR) domain. CC -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M68941; AAA36530.1; -; mRNA. DR EMBL; BC010674; AAH10674.1; -; mRNA. DR PIR; A41105; A41105. DR UniGene; Hs.469809; -. DR PDB; 2CS5; NMR; A=507-612. DR IntAct; P29074; -. DR Ensembl; ENSG00000088179; Homo sapiens. DR KEGG; hsa:5775; -. DR H-InvDB; HIX0002413; -. DR HGNC; HGNC:9656; PTPN4. DR MIM; 176878; gene. DR LinkHub; P29074; -. DR ArrayExpress; P29074; -. DR RZPD-ProtExp; A0131; -. DR RZPD-ProtExp; IOH21070; -. DR GO; GO:0005737; C:cytoplasm; TAS:ProtInc. DR GO; GO:0004726; F:non-membrane spanning protein tyrosine phos...; TAS:ProtInc. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0006470; P:protein amino acid dephosphorylation; TAS:ProtInc. DR InterPro; IPR000299; Band_4.1. DR InterPro; IPR000798; Ez/rad/moesin. DR InterPro; IPR009065; FERM. DR InterPro; IPR001478; PDZ. DR InterPro; IPR011993; PH_type. DR InterPro; IPR012151; Tyr-Ptase_nr3_4. DR InterPro; IPR000387; TYR_phosphatase. DR InterPro; IPR000242; Tyr_PP. DR Pfam; PF00373; Band_41; 1. DR Pfam; PF00595; PDZ; 1. DR Pfam; PF00102; Y_phosphatase; 1. DR PIRSF; PIRSF000927; Tyr-Ptase_nr3; 1. DR PRINTS; PR00935; BAND41. DR PRINTS; PR00661; ERMFAMILY. DR PRINTS; PR00700; PRTYPHPHTASE. DR SMART; SM00295; B41; 1. DR SMART; SM00228; PDZ; 1. DR SMART; SM00194; PTPc; 1. DR PROSITE; PS00660; FERM_1; 1. DR PROSITE; PS00661; FERM_2; 1. DR PROSITE; PS50057; FERM_3; 1. DR PROSITE; PS50106; PDZ; 1. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1. KW 3D-structure; Cytoskeleton; Hydrolase; Protein phosphatase; KW Structural protein. FT CHAIN 1 926 Tyrosine-protein phosphatase non-receptor FT type 4. FT /FTId=PRO_0000219434. FT DOMAIN 29 312 FERM. FT DOMAIN 517 589 PDZ. FT DOMAIN 655 911 Tyrosine-protein phosphatase. FT ACT_SITE 852 852 Phosphocysteine intermediate (By FT similarity). FT STRAND 516 520 FT STRAND 524 526 FT STRAND 529 535 FT HELIX 536 538 FT TURN 539 539 FT STRAND 540 547 FT STRAND 549 551 FT TURN 552 554 FT STRAND 555 558 FT TURN 562 563 FT STRAND 565 569 FT TURN 570 571 FT TURN 574 575 FT HELIX 579 591 FT STRAND 597 602 SQ SEQUENCE 926 AA; 105911 MW; 4DAC6A87A675CFB0 CRC64; MTSRFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFKVNKHDQ GQVLLDVVFK HLDLTEQDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP YSLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILTGRLP CPSNTAALLA SFAVQSELGD YDQSENLSGY LSDYSFIPNQ PQDFEKEIAK LHQQHIGLSP AEAEFNYLNT ARTLELYGVE FHYARDQSNN EIMIGVMSGG ILIYKNRVRM NTFPWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKNLWKA CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN KDRVFARSPS KPLARKLMDW EVVSRNSISD DRLETQSLPS RSPPGTPNHR NSTFTQEGTR LRPSSVGHLV DHMVHTSPSE VFVNQRSPSS TQANSIVLES SPSQETPGDG KPPALPPKQS KKNSWNQIHY SHSQQDLESH INETFDIPSS PEKPTPNGGI PHDNLVLIRM KPDENGRFGF NVKGGYDQKM PVIVSRVAPG TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC ERHSGELMLL VRPNAVYDVV EEKLENEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL ITGTVLTQFD QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG NEDYINANYI NMEIPSSSII NQYIACQGPL PHTCTDFWQM TWEQGSSMVV MLTTQVERGR VKCHQYWPEP TGSSSYGCYQ VTCHSEEGNT AYIFRKMTLF NQEKNESRPL TQIQYIAWPD HGVPDDSSDF LDFVCHVRNK RAGKEEPVVV HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ YRFVCEAILK VYEEGFVKPL TTSTNK //