ID PTN4_HUMAN STANDARD; PRT; 926 AA. AC P29074; DT 01-DEC-1992 (REL. 24, CREATED) DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE PROTEIN-TYROSINE PHOSPHATASE MEG1 (EC 3.1.3.48) (PTPASE-MEG1) (MEG). GN PTPN4. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 91288564. RA GU M., YORK J.D., WARSHAWSKY I., MAJERUS P.W.; RL PROC. NATL. ACAD. SCI. U.S.A. 88:5867-5871(1991). CC -!- FUNCTION: MAY ACT AT JUNCTIONS BETWEEN THE MEMBRANE AND THE CC CYTOSKELETON. CC -!- CATALYTIC ACTIVITY: PROTEIN TYROSINE PHOSPHATE + H(2)O = CC PROTEIN TYROSINE + ORTHOPHOSPHATE. CC -!- SIMILARITY: CONTAINS A DOMAIN FOUND IN BAND 4.1, EZRIN, MOESIN, CC RADIXIN, AND TALIN. CC -!- SIMILARITY: BELONGS TO THE NON-RECEPTOR CLASS OF THE PROTEIN- CC TYROSINE PHOSPHATASE FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M68941; M68941. DR PIR; A41105; A41105. DR HSSP; P18031; 2HNP. DR MIM; 176878; 11TH EDITION. DR PROSITE; PS00383; TYR_PHOSPHATASE. DR PROSITE; PS00660; BAND_41_1. DR PROSITE; PS00661; BAND_41_2. KW STRUCTURAL PROTEIN; CYTOSKELETON; HYDROLASE. FT DOMAIN 84 241 BAND 4.1-LIKE DOMAIN. FT DOMAIN 677 926 PROTEIN-TYROSINE PHOSPHATASE. FT ACT_SITE 852 852 BY SIMILARITY. SQ SEQUENCE 926 AA; 105911 MW; 4547357 CN; MTSRFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFKVNKHDQ GQVLLDVVFK HLDLTEQDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP YSLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILTGRLP CPSNTAALLA SFAVQSELGD YDQSENLSGY LSDYSFIPNQ PQDFEKEIAK LHQQHIGLSP AEAEFNYLNT ARTLELYGVE FHYARDQSNN EIMIGVMSGG ILIYKNRVRM NTFPWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKNLWKA CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN KDRVFARSPS KPLARKLMDW EVVSRNSISD DRLETQSLPS RSPPGTPNHR NSTFTQEGTR LRPSSVGHLV DHMVHTSPSE VFVNQRSPSS TQANSIVLES SPSQETPGDG KPPALPPKQS KKNSWNQIHY SHSQQDLESH INETFDIPSS PEKPTPNGGI PHDNLVLIRM KPDENGRFGF NVKGGYDQKM PVIVSRVAPG TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC ERHSGELMLL VRPNAVYDVV EEKLENEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL ITGTVLTQFD QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG NEDYINANYI NMEIPSSSII NQYIACQGPL PHTCTDFWQM TWEQGSSMVV MLTTQVERGR VKCHQYWPEP TGSSSYGCYQ VTCHSEEGNT AYIFRKMTLF NQEKNESRPL TQIQYIAWPD HGVPDDSSDF LDFVCHVRNK RAGKEEPVVV HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ YRFVCEAILK VYEEGFVKPL TTSTNK //