ID PTN4_HUMAN STANDARD; PRT; 926 AA. AC P29074; DT 01-DEC-1992 (Rel. 24, Created) DT 01-DEC-1992 (Rel. 24, Last sequence update) DT 01-FEB-2005 (Rel. 46, Last annotation update) DE Tyrosine-protein phosphatase, non-receptor type 4 (EC 3.1.3.48) DE (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG). GN Name=PTPN4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=91288564; PubMed=1648233; RA Gu M., York J.D., Warshawsky I., Majerus P.W.; RT "Identification, cloning, and expression of a cytosolic megakaryocyte RT protein-tyrosine-phosphatase with sequence homology to cytoskeletal RT protein 4.1."; RL Proc. Natl. Acad. Sci. U.S.A. 88:5867-5871(1991). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Colon; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: May act at junctions between the membrane and the CC cytoskeleton. CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. CC Non-receptor class subfamily. CC -!- SIMILARITY: Contains 1 FERM domain. CC -!- SIMILARITY: Contains 1 PDZ/DHR domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M68941; AAA36530.1; -. DR EMBL; BC010674; AAH10674.1; -. DR PIR; A41105; A41105. DR HSSP; P11171; 1GG3. DR Ensembl; ENSG00000088179; Homo sapiens. DR Genew; HGNC:9656; PTPN4. DR H-InvDB; HIX0002413; -. DR MIM; 176878; -. DR GO; GO:0005737; C:cytoplasm; TAS. DR GO; GO:0004726; F:non-membrane spanning protein tyrosine phos...; TAS. DR GO; GO:0006470; P:protein amino acid dephosphorylation; TAS. DR InterPro; IPR000299; Band_4.1. DR InterPro; IPR000798; Ez/rad/moesin. DR InterPro; IPR009065; FERM. DR InterPro; IPR001478; PDZ. DR InterPro; IPR011036; PH_related. DR InterPro; IPR000387; TYR_phosphatase. DR InterPro; IPR000242; Tyr_PP. DR Pfam; PF00373; Band_41; 1. DR Pfam; PF00595; PDZ; 1. DR Pfam; PF00102; Y_phosphatase; 1. DR PRINTS; PR00935; BAND41. DR PRINTS; PR00700; PRTYPHPHTASE. DR SMART; SM00295; B41; 1. DR SMART; SM00228; PDZ; 1. DR SMART; SM00194; PTPc; 1. DR PROSITE; PS00660; FERM_1; 1. DR PROSITE; PS00661; FERM_2; 1. DR PROSITE; PS50057; FERM_3; 1. DR PROSITE; PS50106; PDZ; 1. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1. KW Cytoskeleton; Hydrolase; Protein phosphatase; Structural protein. FT DOMAIN 29 312 FERM. FT DOMAIN 517 589 PDZ. FT DOMAIN 677 926 Tyrosine-protein phosphatase. FT ACT_SITE 852 852 Phosphocysteine intermediate (By FT similarity). SQ SEQUENCE 926 AA; 105911 MW; 4DAC6A87A675CFB0 CRC64; MTSRFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFKVNKHDQ GQVLLDVVFK HLDLTEQDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP YSLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILTGRLP CPSNTAALLA SFAVQSELGD YDQSENLSGY LSDYSFIPNQ PQDFEKEIAK LHQQHIGLSP AEAEFNYLNT ARTLELYGVE FHYARDQSNN EIMIGVMSGG ILIYKNRVRM NTFPWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKNLWKA CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN KDRVFARSPS KPLARKLMDW EVVSRNSISD DRLETQSLPS RSPPGTPNHR NSTFTQEGTR LRPSSVGHLV DHMVHTSPSE VFVNQRSPSS TQANSIVLES SPSQETPGDG KPPALPPKQS KKNSWNQIHY SHSQQDLESH INETFDIPSS PEKPTPNGGI PHDNLVLIRM KPDENGRFGF NVKGGYDQKM PVIVSRVAPG TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC ERHSGELMLL VRPNAVYDVV EEKLENEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL ITGTVLTQFD QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG NEDYINANYI NMEIPSSSII NQYIACQGPL PHTCTDFWQM TWEQGSSMVV MLTTQVERGR VKCHQYWPEP TGSSSYGCYQ VTCHSEEGNT AYIFRKMTLF NQEKNESRPL TQIQYIAWPD HGVPDDSSDF LDFVCHVRNK RAGKEEPVVV HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ YRFVCEAILK VYEEGFVKPL TTSTNK //