ID   BLP3_BOMOR     STANDARD;      PRT;   200 AA.
AC   P29004;
DT   01-DEC-1992 (Rel. 24, Created)
DT   01-DEC-1992 (Rel. 24, Last sequence update)
DT   15-JUL-1998 (Rel. 36, Last annotation update)
DE   BOMBININ-LIKE PEPTIDE 3 PRECURSOR (BLP-3).
OS   Bombina orientalis (Oriental fire-bellied toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Archeobatrachia; Bombinatoridae; Bombina.
RN   [1]
RP   SEQUENCE FROM N.A., AND SEQUENCE OF 44-68 AND 105-129.
RC   TISSUE=SKIN;
RX   MEDLINE; 92078177.
RA   Gibson B.W., Tang D., Mandrell R., Kelly M., Spindel E.R.;
RT   "Bombinin-like peptides with antimicrobial activity from skin
RT   secretions of the Asian toad, Bombina orientalis.";
RL   J. Biol. Chem. 266:23103-23111(1991).
CC   -!- FUNCTION: HAS ANTIMICROBIAL ACTIVITY, BUT NO HEMOLYTIC ACTIVITY.
CC       PREFERENCE ON KILLING GRAM-NEGATIVE NON-ENTERIC BACTERIA.
CC   -!- SUBCELLULAR LOCATION: BY VIRTUE OF THEIR SIZE, ALL BOMBININ-LIKE
CC       PEPTIDES ARE CAPABLE OF SPANNING A BILAYER LIPID MEMBRANE.
CC   -!- SIMILARITY: BELONGS TO THE BOMBININ FAMILY.
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DR   EMBL; M76484; AAA73095.1; -.
DR   PIR; C41575; C41575.
KW   Antibiotic; Amidation; Cleavage on pair of basic residues; Signal;
KW   Amphibian skin; Duplication.
FT   SIGNAL        1     16       OR 18.
FT   PEPTIDE      17     43       ACIDIC PEPTIDE 1 (POTENTIAL).
FT   PEPTIDE      44     68       BOMBININ-LIKE PEPTIDE 3.
FT   PEPTIDE      72     79       OCTAPEPTIDE 1 (POTENTIAL).
FT   PEPTIDE      82    104       ACIDIC PEPTIDE 2 (POTENTIAL).
FT   PEPTIDE     105    129       BOMBININ-LIKE PEPTIDE 3.
FT   PEPTIDE     133    140       OCTAPEPTIDE 2 (POTENTIAL).
FT   PEPTIDE     143    177       ACIDIC PEPTIDE 3 (POTENTIAL).
FT   PEPTIDE     183    200       HYDROPHOBIC PEPTIDE (POTENTIAL).
FT   MOD_RES      68     68       AMIDATION (G-69 PROVIDE AMIDE GROUP).
FT   MOD_RES     129    129       AMIDATION (G-130 PROVIDE AMIDE GROUP).
SQ   SEQUENCE   200 AA;  21934 MW;  1185F0836BF8A277 CRC64;
     MNFKYIVAVS ILIASAYARS EENDIQSLSQ RDVLEEESLR EIRGIGAAIL SAGKSALKGL
     AKGLAEHFGK RTAEDHEVMK RLEAAIHSLS QRDVLEEESL REIRGIGAAI LSAGKSALKG
     LAKGLAEHFG KRTAEEHEMM KRLEAVMRDL DSLDYPEEAS EMETRSFNQE EIANLYTKKE
     KRILGPILGL VSNALGGLLG
//