ID V1A_TAV STANDARD; PRT; 993 AA. AC P28931; DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-1992, sequence version 1. DT 07-FEB-2006, entry version 26. DE Protein 1A [Includes: ATP-dependent helicase (EC 3.6.1.-); DE Methyltransferase]. GN Name=RNA1; OS Tomato aspermy virus (TAV). OC Viruses; ssRNA positive-strand viruses, no DNA stage; Bromoviridae; OC Cucumovirus. OX NCBI_TaxID=12315; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RC STRAIN=V; RX MEDLINE=91374017; PubMed=1895056; RA Bernal J.J., Moriones E., Garcia-Arenal F.; RT "Evolutionary relationships in the cucumoviruses: nucleotide sequence RT of tomato aspermy virus RNA 1."; RL J. Gen. Virol. 72:2191-2195(1991). CC -!- FUNCTION: May be involved in the replication of the virus. CC Contains an helicase domain and a methyltransferase domain. The CC methyltransferase domain is probably involved in viral RNA CC capping. CC -!- MISCELLANEOUS: The virus has a tripartite genome (RNA1, RNA2 and CC RNA3) and an encapsidated subgenomic RNA (RNA4) from which the CC coat protein is expressed. Virions are icosahedral, not enveloped, CC with 32 capsomeres per nucleocapsid. CC -!- SIMILARITY: Belongs to the cucumoviruses/bromoviruses 1A family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D10044; BAA00936.1; -; Genomic_RNA. DR PIR; JQ1370; P1VXTA. DR InterPro; IPR002588; V_methyltrans. DR InterPro; IPR000606; Viral_helicase1. DR Pfam; PF01443; Viral_helicase1; 1. DR Pfam; PF01660; Vmethyltransf; 1. KW ATP-binding; Helicase; Hydrolase; Methyltransferase; KW Nucleotide-binding; Transferase. FT CHAIN 1 993 Protein 1A. FT /FTId=PRO_0000083266. FT NP_BIND 714 721 ATP (Potential). SQ SEQUENCE 993 AA; 112062 MW; 516926DD910FF4EA CRC64; MAASAFNIHK LVASHGDKGL LASALVDKLA HEQLEEQVQH QRRGLKVYIR NALDVKDSEI IRDRYGGKYD LHLTQQEQAP HGLAGALRLC ELLDCLDSFP RTGLRQDLVL DFGGSWVTHY LRGHNVHCCS PCLGIRDKMR HTERLMTMRK VIVNDPDTFE SRVPDFCTLP AEDCKVQAHF VISIHGGYDM GFKGLCRAMH AHGTTFLKGT MMFDGAMLFD TEGYLADLKC KWKKIKPRTY ESEDQTPLLS RISDNLTTTI KDHTLIAFDF VDESTLSYVH KWENVKSFLT DQTYSYKGMT YGLERCLIQH GIMTYKIIAV PGTCPPELIR HCIWFTSLKD YVGLKIPVSQ DLVEWKTVRI LISTLRETEE IAMRCYSDKK NWLEQFKVIL GVLSSKSSTI VINGMAMQAG ERIDTSDYHY IGLAILLHTR MKYEQLGRMY DMWNSTFIRK FFASLTRPMR VFLSACVKTL FPTLRPRDEK EFLVKLSTFV TFNEVCQVDL DAEWDVISSA AFTAEMAVED GKRLAEDRKQ KAEAASQIPV DEIPDDTAES SDDTPREADT NQKSEPSSPE LETLSTQTRS PITRLAQRAS SMLEYSAYEA QLHDNAVSNL DRMWCMAGGD KKNNRLESNV KFVFETYHIV DPLVNVHFPT GRWLYRVPEG ISYSVGFNEH GIGPKADGEL YIVNADCVIS NSKCLADTTL QYLAPTGTIS LVDGVAGCGK TTAIKKMFNP ATDVIVTANK KSALDVRQAL FNCTDSKEAT TFVRTADSIL MNDTNEVQRV LVDEVVLLHF GQLCAVMSKL KAVRAICFGD SEQIAFCSRD ASFDMRHSTI IPDETDTADT TFRSPQDVIK VVKCMASKAL KKGTHSKYAS WVSQSKVQRS VSSKAVASVT MVDLTEDRFY ITMTQADKTA LRTRARELNM SNDFIEHRIK TTHESQGVSE DHVTLVRLKT TKCDLFKAFK YCLVAVTRHK KTFRYEHVGK LDGDLIAECL ARV //