ID SAHH_RHOCA STANDARD; PRT; 463 AA. AC P28183; DT 01-DEC-1992 (REL. 24, CREATED) DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE ADENOSYLHOMOCYSTEINASE (EC 3.3.1.1) (S-ADENOSYL-L-HOMOCYSTEINE DE HYDROLASE) (ADOHCYASE). GN AHCY. OS RHODOBACTER CAPSULATUS (RHODOPSEUDOMONAS CAPSULATA). OC PROKARYOTA; GRACILICUTES; ANOXYPHOTOBACTERIA; PURPLE BACTERIA; OC RHODOSPIRILLACEAE. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=SB1003 / ST LOUIS; RX MEDLINE; 92335291. RA SGANGA M.W., AKSAMIT R.R., CANTONI G.L., BAUER C.E.; RL PROC. NATL. ACAD. SCI. U.S.A. 89:6328-6332(1992). RN [2] RP SEQUENCE OF 1-13 FROM N.A. RC STRAIN=SB1003 / ST LOUIS; RX MEDLINE; 94110241. RA BUGGY J.J., SGANGA M.W., BAUER C.E.; RL J. BACTERIOL. 176:61-69(1994). CC -!- FUNCTION: ADENOSYLHOMOCYSTEINE IS A COMPETITIVE INHIBITOR OF CC S-ADENOSYL-L-METHININE-DEPENDENT METHYL TRANSFERASE REACTIONS; CC THEREFORE ADENOSYLHOMOCYSTEINASE MAY PLAY A KEY ROLE IN THE CC CONTROL OF METHYLATIONS VIA REGULATION OF THE INTRACELLULAR CC CONCENTRATION OF ADENOSYLHOMOCYSTEINE. CC -!- CATALYTIC ACTIVITY: S-ADENOSYL-L-HOMOCYSTEINE + H(2)O = CC ADENOSINE + L-HOMOCYSTEINE. CC -!- COFACTOR: NAD. CC -!- PATHWAY: ACTIVATED METHYL CYCLE. CC -!- SUBUNIT: HOMOTETRAMER. CC -!- SIMILARITY: WITH OTHER SPECIES' ADENOSYLHOMOCYSTEINASE. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M80630; M80630. DR EMBL; L23836; L23836. DR PROSITE; PS00738; ADOHCYASE_1. DR PROSITE; PS00739; ADOHCYASE_2. KW HYDROLASE; NAD; ONE-CARBON METABOLISM. FT NP_BIND 247 278 NAD (POTENTIAL). SQ SEQUENCE 463 AA; 50580 MW; 1100120 CN; MADYIVKDIK LAEFGRKELD IAETEMPGLM ACREEFGPSQ PLKGARIAGS LHMTIQTAVL IETLKALGAD VRWASCNIFS TQDHAAAAIA AGGTPVFAVK GETLEEYWAY TDKIFQFPEG TCNMILDDGG DATLYILLGA RVEAGETDLI ATPTSEDEVC LFNQIKKRMV ESPGWFTQQR AAIKGVSEET TTGVHRLYDL HKKGLLPFPA INVNDSVTKS KFDNKYGCKE SLVDGIRRAT DVMMAGKVAV VCGYGDVGKG SAASLRGAGA RVKVTEVDPI CALQAAMDGF EVVVLEDVVA DADIFITTTG NKDVIRIEHM REMKDMAIVG NIGHFDNEIQ VAALKNHKWT NIKDQVDMIE MPSGARIILL SEGRLLNLGN ATGHPSFVMS ASFTNQVLAQ IELWTKGAEY QPGVYILPKS LDEKVARLHL KKIGVKLTTL RPDQAEYIGV TVEGPFKSDH YRY //