ID HEMA_MEASY STANDARD; PRT; 620 AA. AC P28081; DT 01-AUG-1992 (REL. 23, CREATED) DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE) DT 01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE) DE HEMAGGLUTININ-NEURAMINIDASE (EC 3.2.1.18). GN HN. OS MEASLES VIRUS (STRAIN YAMAGATA-1) (SUBACUTE SCLEROSE PANENCEPHALITIS OS VIRUS). OC VIRUSES; SSRNA NEGATIVE-STRAND VIRUSES; MONONEGAVIRALES; OC PARAMYXOVIRIDAE; PARAMYXOVIRINAE; MORBILLIVIRUS. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 90385701. RA KOMASE K., HAGA T., YOSHIKAWA Y., SATO T.A., YAMANOUCHI K.; RT "Molecular analysis of structural protein genes of the Yamagata-1 RT strain of defective subacute sclerosing panencephalitis virus. III. RT Nucleotide sequence of the hemagglutinin gene."; RL VIRUS GENES 4:163-172(1990). CC -!- FUNCTION: HEMAGGLUTININ IS RESPONSIBLE FOR ATTACHING THE VIRUS CC TO CELL RECEPTORS AND FOR INITIATING INFECTION. NEUROAMINIDASE CC ACTIVITY HELPS THE EFFICIENT SPREAD OF THE VIRUS BY DISSOCIATING CC THE MATURE VIRIONS FROM THE NEURAMINIC ACID CONTAINING CC GLYCOPROTEINS. CC -!- SUBCELLULAR LOCATION: EXTERNAL, ANCHORED TO THE ENVELOPE BY ITS CC N-TERMINAL HYDROPHOBIC SEQUENCE. CC -!- SIMILARITY: BELONGS TO THE PARAMYXOVIRUSES HEMAGGLUTININ- CC NEURAMINIDASE FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D10549; G222259; -. DR PIR; JU0273; JU0273. DR PFAM; PF00423; HN; 1. KW HYDROLASE; HEMAGGLUTININ; ENVELOPE PROTEIN; GLYCOPROTEIN; KW TRANSMEMBRANE. FT DOMAIN 1 34 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 35 58 MEMBRANE ANCHOR (POTENTIAL). FT DOMAIN 59 620 EXTRACELLULAR (POTENTIAL). FT CARBOHYD 168 168 POTENTIAL. FT CARBOHYD 187 187 POTENTIAL. FT CARBOHYD 200 200 POTENTIAL. FT CARBOHYD 215 215 POTENTIAL. FT CARBOHYD 238 238 POTENTIAL. SQ SEQUENCE 620 AA; 69601 MW; 12653606 CRC32; MSPQRDRTNA FYKDNPHPKG SRIVINREHL MIDRPYVLLA ILFVMFLSLI GLLAIAGIRL HQAAIHTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLNWCI NPPERIKLDY DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN MSTSLLDLYL SRGYNVSSIV TMTSQGMYGG TYLVEKPNLS SKRSELSQLS MYRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDLSNCMVA LGEFKLAALC HREDSITIPY QGSGKGVSFQ LVNLGVWKSP TDMQSWIPLS TDDPVIDRLY LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA PLKDNRIPSY GVLSVDLSPT VELKIKIASG FGPLITHGSG MDLYKSNHNN VYWLTIPPMK NLALGVINTL EWIPRFKVSP NLFTVPIKEA GKDCHAPTYL PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPGRSFS YFYPFRLPIR GVPIELQVEC FTWDQKLWCR HFCVLANSES GGHITHSGMV GMGVSCTVTR EDGTNRRQSC //