ID HEMA_MEASY Reviewed; 620 AA. AC P28081; DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-1992, sequence version 2. DT 02-MAR-2010, entry version 55. DE RecName: Full=Hemagglutinin glycoprotein; GN Name=H; OS Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose OS panencephalitis virus). OC Viruses; ssRNA negative-strand viruses; Mononegavirales; OC Paramyxoviridae; Paramyxovirinae; Morbillivirus. OX NCBI_TaxID=11239; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=90385701; PubMed=2402882; DOI=10.1007/BF00678407; RA Komase K., Haga T., Yoshikawa Y., Sato T.A., Yamanouchi K.; RT "Molecular analysis of structural protein genes of the Yamagata-1 RT strain of defective subacute sclerosing panencephalitis virus. III. RT Nucleotide sequence of the hemagglutinin gene."; RL Virus Genes 4:163-172(1990). CC -!- FUNCTION: Attaches the virus to cell receptors and thereby CC initiating infection. Binding of H protein to the receptor induces CC a conformational change that allows the F protein to trigger CC virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as CC receptors for viral entry into the cell. The high degree of CC interaction between H and MCP/CD46 results in down-regulation of CC the latter from the surface of infected cells, rendering them more CC sensitive to c3b-mediated complement lysis (By similarity). CC -!- SUBUNIT: Interacts with human MCP/CD46 antigen and SLAMF1 (By CC similarity). CC -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass type II CC membrane protein (Potential). Host cell membrane; Single-pass type CC II membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin- CC neuraminidase family. Non-sialidase subfamily. CC -!- CAUTION: Morbiliviruses hemagglutinins have no neuraminidase CC activity. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D10549; BAA01406.1; -; mRNA. DR PIR; JU0273; JU0273. DR SMR; P28081; 157-607. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro. DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro. DR GO; GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW. DR GO; GO:0019058; P:viral infectious cycle; IEA:InterPro. DR InterPro; IPR000665; Hemagglutn-neuramid_glycoprot. DR InterPro; IPR011040; Neuraminidase. DR Pfam; PF00423; HN; 1. DR SUPFAM; SSF50939; Sialidase; 1. PE 2: Evidence at transcript level; KW Envelope protein; Glycoprotein; Hemagglutinin; Host cell membrane; KW Host membrane; Host-virus interaction; Membrane; Signal-anchor; KW Transmembrane; Virion. FT CHAIN 1 620 Hemagglutinin glycoprotein. FT /FTId=PRO_0000142602. FT TOPO_DOM 1 37 Cytoplasmic (Potential). FT TRANSMEM 38 58 Membrane anchor (Potential). FT TOPO_DOM 59 620 Extracellular (Potential). FT CARBOHYD 168 168 N-linked (GlcNAc...); by host FT (Potential). FT CARBOHYD 187 187 N-linked (GlcNAc...); by host FT (Potential). FT CARBOHYD 200 200 N-linked (GlcNAc...); by host FT (Potential). FT CARBOHYD 215 215 N-linked (GlcNAc...); by host FT (Potential). FT CARBOHYD 238 238 N-linked (GlcNAc...); by host FT (Potential). SQ SEQUENCE 620 AA; 69602 MW; 30641B0DA2B48A68 CRC64; MSPQRDRTNA FYKDNPHPKG SRIVINREHL MIDRPYVLLA ILFVMFLSLI GLLAIAGIRL HQAAIHTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLNWCI NPPERIKLDY DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN MSTSLLDLYL SRGYNVSSIV TMTSQGMYGG TYLVEKPNLS SKRSELSQLS MYRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDLSNCMVA LGEFKLAALC HREDSITIPY QGSGKGVSFQ LVNLGVWKSP TDMQSWIPLS TDDPVIDRLY LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA PLKDNRIPSY GVLSVDLSPT VELKIKIASG FGPLITHGSG MDLYKSNHNN VYWLTIPPMK NLALGVINTL EWIPRFKVSP NLFTVPIKEA GKDCHAPTYL PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPGRSFS YFYPFRLPIR GVPIELQVEC FTWDQKLWCR HFCVLANSES GGHITHSGMV GMGVSCTVTR EDGTNRRQSC //