ID HEMA_MEASY STANDARD; PRT; 620 AA. AC P28081; DT 01-AUG-1992 (REL. 23, CREATED) DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE) DT 01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE) DE HEMAGGLUTININ-NEURAMINIDASE (EC 3.2.1.18). GN HN. OS MEASLES VIRUS (STRAIN YAMAGATA-1) (SUBACUTE SCLEROSE PANENCEPHALITIS OS VIRUS). OC VIRIDAE; SS-RNA ENVELOPED VIRUSES; NEGATIVE-STRAND; PARAMYXOVIRIDAE; OC MORBILLIVIRUSES. RN [1] RP SEQUENCE FROM N.A. RM 90385701 RA KOMASE K., HAGA T., YOSHIKAWA Y., SATO T.A., YAMANOUCHI K.; RL VIRUS GENES 4:163-172(1990). CC -!- FUNCTION: HEMAGGLUTININ IS RESPONSIBLE FOR ATTACHING THE VIRUS CC TO CELL RECEPTORS AND FOR INITIATING INFECTION. NEUROAMINIDASE CC ACTIVITY HELPS THE EFFICIENT SPREAD OF THE VIRUS BY DISSOCIATING CC THE MATURE VIRIONS FROM THE NEURAMINIC ACID CONTAINING CC GLYCOPROTEINS. CC -!- SUBCELLULAR LOCATION: EXTERNAL, ANCHORED TO THE ENVELOPE BY ITS CC N-TERMINAL HYDROPHOBIC SEQUENCE. CC -!- SIMILARITY: TO HEMAGGLUTININ-NEURAMINIDASES FROM OTHER CC PARAMYXOVIRUSES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D10549; PEVHP. DR PIR; JU0273; JU0273. KW HYDROLASE; HEMAGGLUTININ; ENVELOPE PROTEIN; GLYCOPROTEIN; KW TRANSMEMBRANE. FT DOMAIN 1 34 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 35 58 MEMBRANE ANCHOR (POTENTIAL). FT DOMAIN 59 620 EXTRACELLULAR (POTENTIAL). FT CARBOHYD 168 168 POTENTIAL. FT CARBOHYD 187 187 POTENTIAL. FT CARBOHYD 200 200 POTENTIAL. FT CARBOHYD 215 215 POTENTIAL. FT CARBOHYD 238 238 POTENTIAL. SQ SEQUENCE 620 AA; 69601 MW; 2119432 CN; MSPQRDRTNA FYKDNPHPKG SRIVINREHL MIDRPYVLLA ILFVMFLSLI GLLAIAGIRL HQAAIHTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLNWCI NPPERIKLDY DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN MSTSLLDLYL SRGYNVSSIV TMTSQGMYGG TYLVEKPNLS SKRSELSQLS MYRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDLSNCMVA LGEFKLAALC HREDSITIPY QGSGKGVSFQ LVNLGVWKSP TDMQSWIPLS TDDPVIDRLY LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA PLKDNRIPSY GVLSVDLSPT VELKIKIASG FGPLITHGSG MDLYKSNHNN VYWLTIPPMK NLALGVINTL EWIPRFKVSP NLFTVPIKEA GKDCHAPTYL PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPGRSFS YFYPFRLPIR GVPIELQVEC FTWDQKLWCR HFCVLANSES GGHITHSGMV GMGVSCTVTR EDGTNRRQSC //