ID HEMA_MEASY STANDARD; PRT; 620 AA. AC P28081; DT 01-AUG-1992 (Rel. 23, Created) DT 01-DEC-1992 (Rel. 24, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Hemagglutinin-neuraminidase (EC 3.2.1.18). GN HN. OS Measles virus (strain Yamagata-1) (Subacute sclerose panencephalitis OS virus). OC Viruses; ssRNA negative-strand viruses; Mononegavirales; OC Paramyxoviridae; Paramyxovirinae; Morbillivirus. OX NCBI_TaxID=11239; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=90385701; PubMed=2402882; RA Komase K., Haga T., Yoshikawa Y., Sato T.A., Yamanouchi K.; RT "Molecular analysis of structural protein genes of the Yamagata-1 RT strain of defective subacute sclerosing panencephalitis virus. III. RT Nucleotide sequence of the hemagglutinin gene."; RL Virus Genes 4:163-172(1990). CC -!- FUNCTION: HEMAGGLUTININ IS RESPONSIBLE FOR ATTACHING THE VIRUS CC TO CELL RECEPTORS AND FOR INITIATING INFECTION. NEURAMINIDASE CC ACTIVITY HELPS THE EFFICIENT SPREAD OF THE VIRUS BY DISSOCIATING CC THE MATURE VIRIONS FROM THE NEURAMINIC ACID CONTAINING CC GLYCOPROTEINS. CC -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, CC alpha-(2->8)-glycosidic linkages of terminal sialic residues in CC oligosaccharides, glycoproteins, glycolipids, colominic acid and CC synthetic substrates. CC -!- SUBCELLULAR LOCATION: EXTERNAL, ANCHORED TO THE ENVELOPE BY ITS CC N-TERMINAL HYDROPHOBIC SEQUENCE. CC -!- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin- CC neuraminidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D10549; BAA01406.1; -. DR PIR; JU0273; JU0273. DR InterPro; IPR000665; Hem-neuramndse. DR Pfam; PF00423; HN; 1. KW Hydrolase; Hemagglutinin; Envelope protein; Glycoprotein; KW Transmembrane. FT DOMAIN 1 34 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 35 58 MEMBRANE ANCHOR (POTENTIAL). FT DOMAIN 59 620 EXTRACELLULAR (POTENTIAL). FT CARBOHYD 168 168 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 187 187 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 200 200 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 215 215 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 238 238 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 620 AA; 69601 MW; 30641B0DA2B48A68 CRC64; MSPQRDRTNA FYKDNPHPKG SRIVINREHL MIDRPYVLLA ILFVMFLSLI GLLAIAGIRL HQAAIHTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLNWCI NPPERIKLDY DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN MSTSLLDLYL SRGYNVSSIV TMTSQGMYGG TYLVEKPNLS SKRSELSQLS MYRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDLSNCMVA LGEFKLAALC HREDSITIPY QGSGKGVSFQ LVNLGVWKSP TDMQSWIPLS TDDPVIDRLY LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA PLKDNRIPSY GVLSVDLSPT VELKIKIASG FGPLITHGSG MDLYKSNHNN VYWLTIPPMK NLALGVINTL EWIPRFKVSP NLFTVPIKEA GKDCHAPTYL PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPGRSFS YFYPFRLPIR GVPIELQVEC FTWDQKLWCR HFCVLANSES GGHITHSGMV GMGVSCTVTR EDGTNRRQSC //