ID TMD11_CANFA Reviewed; 215 AA. AC P27869; DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1992, sequence version 1. DT 11-JUN-2014, entry version 81. DE RecName: Full=Transmembrane emp24 domain-containing protein 11; DE AltName: Full=Glycoprotein 25L; DE Short=GP25L; DE AltName: Full=p24 family protein alpha-1; DE Short=p24alpha1; DE Flags: Precursor; GN Name=TMED11; OS Canis familiaris (Dog) (Canis lupus familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE. RC TISSUE=Pancreas; RX PubMed=1918067; RA Wada I., Rindress D., Cameron P.H., Ou W.-J., Doherty J.J. II, RA Louvard D., Bell A.W., Dignard D., Thomas D.Y., Bergeron J.J.M.; RT "SSR alpha and associated calnexin are major calcium binding proteins RT of the endoplasmic reticulum membrane."; RL J. Biol. Chem. 266:19599-19610(1991). CC -!- FUNCTION: Part of a complex whose function is to bind Ca(2+) to CC the ER membrane and thereby regulate the retention of ER resident CC proteins. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass CC type I membrane protein. CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. CC -!- SIMILARITY: Contains 1 GOLD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X53592; CAA37662.1; -; mRNA. DR PIR; C37273; C37273. DR RefSeq; NP_001003286.1; NM_001003286.1. DR UniGene; Cfa.3838; -. DR STRING; 9615.ENSCAFP00000024552; -. DR Ensembl; ENSCAFT00000026438; ENSCAFP00000024552; ENSCAFG00000016696. DR GeneID; 403969; -. DR KEGG; cfa:403969; -. DR CTD; 67366; -. DR eggNOG; NOG323830; -. DR GeneTree; ENSGT00430000030848; -. DR HOVERGEN; HBG105357; -. DR InParanoid; P27869; -. DR OMA; SGEHIIC; -. DR OrthoDB; EOG74BJT2; -. DR TreeFam; TF314123; -. DR NextBio; 20817459; -. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006810; P:transport; IEA:InterPro. DR InterPro; IPR009038; GOLD. DR InterPro; IPR015719; TMED11. DR InterPro; IPR015720; TMP21-related. DR PANTHER; PTHR22811; PTHR22811; 1. DR PANTHER; PTHR22811:SF3; PTHR22811:SF3; 1. DR Pfam; PF01105; EMP24_GP25L; 1. DR PROSITE; PS50866; GOLD; 1. PE 1: Evidence at protein level; KW Coiled coil; Complete proteome; Direct protein sequencing; KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 17 FT CHAIN 18 215 Transmembrane emp24 domain-containing FT protein 11. FT /FTId=PRO_0000010378. FT TOPO_DOM 18 167 Lumenal (Potential). FT TRANSMEM 168 185 Helical; (Potential). FT TOPO_DOM 186 215 Cytoplasmic (Potential). FT DOMAIN 27 125 GOLD. FT COILED 129 171 Potential. FT MOTIF 208 215 COPI vesicle coat-binding (Potential). FT MOTIF 208 209 COPII vesicle coat-binding (Potential). FT CARBOHYD 105 105 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 215 AA; 24882 MW; 4A0DA7DFD0075815 CRC64; MPMLAFALSF YFSLSTAFYF HVGEREEKCI IEDIPSDTLV TGTFKTQQWD FRRQDFLESA PGLGMFVTVT TYNDEVLLSK LYGPQGRFYF TSHSPGEHII CLESNSTRLV SFGGSKLRIH LEIRVGQHDL DAAIAQAKDK VNEVSFKLEH LIEQIEQIVK EQNYQRDREE NFRMISEDTN SNVLWWAFAQ TLIFIAIGIF QMKSLKNFFI AKKLV //