ID G25L_CANFA Reviewed; 215 AA. AC P27869; DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1992, sequence version 1. DT 25-NOV-2008, entry version 47. DE RecName: Full=Glycoprotein 25L; DE Short=GP25L; DE Flags: Precursor; OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE. RC TISSUE=Pancreas; RX MEDLINE=92011761; PubMed=1918067; RA Wada I., Rindress D., Cameron P.H., Ou W.-J., Doherty J.J. II, RA Louvard D., Bell A.W., Dignard D., Thomas D.Y., Bergeron J.J.M.; RT "SSR alpha and associated calnexin are major calcium binding proteins RT of the endoplasmic reticulum membrane."; RL J. Biol. Chem. 266:19599-19610(1991). CC -!- FUNCTION: Part of a complex whose function is to bind Ca(2+) to CC the ER membrane and thereby regulate the retention of ER resident CC proteins. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass CC type I membrane protein. CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. CC -!- SIMILARITY: Contains 1 GOLD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X53592; CAA37662.1; -; mRNA. DR PIR; C37273; C37273. DR RefSeq; NP_001003286.1; -. DR UniGene; Cfa.3838; -. DR Ensembl; ENSCAFG00000016696; Canis familiaris. DR GeneID; 403969; -. DR KEGG; cfa:403969; -. DR HOVERGEN; P27869; -. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral to membrane; IEA:InterPro. DR GO; GO:0006810; P:transport; IEA:InterPro. DR InterPro; IPR000348; Emp24_gp25L_p24. DR InterPro; IPR015719; Glycprot_25L_rel. DR InterPro; IPR009038; GOLD. DR PANTHER; PTHR22811:SF3; Glycprot_25L_rel; 1. DR Pfam; PF01105; EMP24_GP25L; 1. DR PROSITE; PS50866; GOLD; 1. PE 1: Evidence at protein level; KW Coiled coil; Direct protein sequencing; Endoplasmic reticulum; KW Glycoprotein; Membrane; Signal; Transmembrane. FT SIGNAL 1 17 FT CHAIN 18 215 Glycoprotein 25L. FT /FTId=PRO_0000010378. FT TOPO_DOM 18 167 Lumenal (Potential). FT TRANSMEM 168 185 Potential. FT TOPO_DOM 186 215 Cytoplasmic (Potential). FT DOMAIN 27 125 GOLD. FT COILED 129 171 Potential. FT MOTIF 212 215 Prevents secretion from ER. FT CARBOHYD 105 105 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 215 AA; 24882 MW; 4A0DA7DFD0075815 CRC64; MPMLAFALSF YFSLSTAFYF HVGEREEKCI IEDIPSDTLV TGTFKTQQWD FRRQDFLESA PGLGMFVTVT TYNDEVLLSK LYGPQGRFYF TSHSPGEHII CLESNSTRLV SFGGSKLRIH LEIRVGQHDL DAAIAQAKDK VNEVSFKLEH LIEQIEQIVK EQNYQRDREE NFRMISEDTN SNVLWWAFAQ TLIFIAIGIF QMKSLKNFFI AKKLV //