ID G25L_CANFA STANDARD; PRT; 215 AA. AC P27869; DT 01-AUG-1992 (Rel. 23, Created) DT 01-AUG-1992 (Rel. 23, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Glycoprotein 25L precursor (GP25L). OS Canis familiaris (Dog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. RC TISSUE=Pancreas; RX MEDLINE=92011761; PubMed=1918067; RA Wada I., Rindress D., Cameron P.H., Ou W.-J., Doherty J.J. II, RA Louvard D., Bell A.W., Dignard D., Thomas D.Y., Bergeron J.J.M.; RT "SSR alpha and associated calnexin are major calcium binding proteins RT of the endoplasmic reticulum membrane."; RL J. Biol. Chem. 266:19599-19610(1991). CC -!- FUNCTION: PART OF A COMPLEX WHOSE FUNCTION IS TO BIND CA(2+) TO CC THE ER MEMBRANE AND THEREBY REGULATE THE RETENTION OF ER RESIDENT CC PROTEINS. CC -!- SUBCELLULAR LOCATION: Type I membrane protein. Endoplasmic CC reticulum. CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. CC -!- SIMILARITY: Contains 1 GOLD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X53592; CAA37662.1; -. DR PIR; C37273; C37273. DR InterPro; IPR000348; Emp24_gp25L_p24. DR InterPro; IPR009038; GOLD. DR Pfam; PF01105; EMP24_GP25L; 1. DR PROSITE; PS50866; GOLD; 1. KW Glycoprotein; Signal; Endoplasmic reticulum; Transmembrane. FT SIGNAL 1 17 FT CHAIN 18 215 GLYCOPROTEIN 25L. FT DOMAIN 18 167 LUMENAL (POTENTIAL). FT TRANSMEM 168 185 POTENTIAL. FT DOMAIN 186 215 CYTOPLASMIC (POTENTIAL). FT DOMAIN 27 125 GOLD. FT SITE 212 215 PREVENT SECRETION FROM ER. FT CARBOHYD 105 105 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 215 AA; 24882 MW; 4A0DA7DFD0075815 CRC64; MPMLAFALSF YFSLSTAFYF HVGEREEKCI IEDIPSDTLV TGTFKTQQWD FRRQDFLESA PGLGMFVTVT TYNDEVLLSK LYGPQGRFYF TSHSPGEHII CLESNSTRLV SFGGSKLRIH LEIRVGQHDL DAAIAQAKDK VNEVSFKLEH LIEQIEQIVK EQNYQRDREE NFRMISEDTN SNVLWWAFAQ TLIFIAIGIF QMKSLKNFFI AKKLV //