ID CALX_HUMAN STANDARD; PRT; 592 AA. AC P27824; DT 01-AUG-1992 (REL. 23, CREATED) DT 01-AUG-1992 (REL. 23, LAST SEQUENCE UPDATE) DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE) DE CALNEXIN PRECURSOR (MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I DE ANTIGEN-BINDING PROTEIN P88) (P90). OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RA HONORE B., LEFFERS H., MADSEN P., CELIS J.E.; RL SUBMITTED (JUN-1992) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [2] RP SEQUENCE OF 237-592 FROM N.A. RM 92409534 RA GALVIN K., KRISHNA S., PONCHEL F., FROHLICH M., CUMMINGS D.E., RA CARLSON R., WANDS J.R., ISSELBACHER K.J., PILLAI S., OZTURK M.; RL PROC. NATL. ACAD. SCI. U.S.A. 89:8452-8456(1992). CC -!- FUNCTION: CALNEXIN IS PART OF A COMPLEX WHOSE FUNCTION IS TO BIND CC CA(2+) TO THE ER MEMBRANE AND THEREBY REGULATE THE RETENTION CC OF ER RESIDENT PROTEINS. CC -!- SUBUNIT: HETEROTETRAMER OF A PHOSPHOPROTEIN (CALNEXIN), A CC PHOSPHOGLYCOPROTEIN (SSR-ALPHA/PGP35), AND TWO GLYCOPROTEINS CC (SSR-BETA/GP25H) AND GP25L. CC -!- SUBCELLULAR LOCATION: ENDOPLASMIC RETICULUM MEMBRANE. CC -!- SIMILARITY: TO CALRETICULIN. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M94859; HSCALIEF. DR EMBL; M98452; HSCLNXN. DR PROSITE; PS00803; CALRETICULIN_1. DR PROSITE; PS00804; CALRETICULIN_2. DR PROSITE; PS00805; CALRETICULIN_REPEAT. KW CALCIUM-BINDING; ENDOPLASMIC RETICULUM; TRANSMEMBRANE; SIGNAL; KW TANDEM REPEAT. FT SIGNAL 1 ? FT CHAIN ? 592 CALNEXIN. FT DOMAIN ? 462 LUMENAL (POTENTIAL). FT TRANSMEM 482 502 POTENTIAL. FT DOMAIN 503 592 CYTOSOLIC (POTENTIAL). FT REPEAT 273 289 FT REPEAT 290 306 FT REPEAT 309 325 FT REPEAT 328 344 FT CONFLICT 431 433 SDI -> LTF (IN REF. 2). FT CONFLICT 480 480 R -> L (IN REF. 2). SQ SEQUENCE 592 AA; 67534 MW; 1712143 CN; MEGKWLLCML LVLGTAIVEA HDGHDDDVID IEDDLDDVIE EVEDSKPDTT APPSSPKVTY KAPVPTGEVY FADSFDRGTL SGWILSKAKK DDTDDEIAKY DGKWEVEEMK ESKLPGDKGL VLMSRAKHHA ISAKLNKPFL FDTKPLIVQY EVNFQNGIEC GGAYVKLLSK TPELNLDQLH DKTPYTIMFG PDKCGEDYKL HFIFRHKNPK TGIYEEKHAK RPDADLKTYF TDKKTHLYTL ILNPDNSFEI LVDQSVVNSG NLLNDMTPPV NPSREIEDPE DRKPEDWDER PKIPDPEAVK PDDWDEDAPA KIPDEEATKP EGWLDDEPEY VPDPDAEKPE DWDEDMDGEW EAPQIANPRC ESAPGCGVWQ RPVIDNPNYK GKWKPPMIDN PSYQGIWKPR KIPNPDFFED LEPFRMTPFS AIGLELWSMT SDIFFDNFII CADRRIVDDW ANDGWGLKKA ADGAAEPGVV GQMIEAAEER PWLWVVYILT VALPVFLVIL FCCSGKKQTS GMEYKKTDAP QPDVKEEEEE KEEEKDKGDE EEEGEEKLEE KQKSDAEEDG GTVSQEEEDR KPKAEEDEIL NRSPRNRKPR RE //