ID SYV_HUMAN STANDARD; PRT; 1263 AA. AC P26640; DT 01-AUG-1992 (REL. 23, CREATED) DT 01-FEB-1996 (REL. 33, LAST SEQUENCE UPDATE) DT 01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE) DE VALYL-TRNA SYNTHETASE (EC 6.1.1.9) (VALINE--TRNA LIGASE) (VALRS). GN VARS1 OR VARS. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 91378943. RA HSIEH H.-L., CAMPBELL R.D.; RL BIOCHEM. J. 278:809-816(1991). RN [2] RP SEQUENCE OF 201-1263 FROM N.A. RX MEDLINE; 93154582. RA VILALTA A., DONOVAN D., WOOD L., VOGELI G., YANG D.C.H.; RL GENE 123:181-186(1993). CC -!- CATALYTIC ACTIVITY: ATP + L-VALINE + TRNA(VAL) = AMP + CC PYROPHOSPHATE + L-VALYL-TRNA(VAL). CC -!- ENZYME REGULATION: CAN BE REGULATED BY PROTEIN KINASE C-DEPENDENT CC PHOSPHORYLATION. CC -!- SUBUNIT: FORMS HIGH-MOLECULAR-MASS AGGREGATES WITH ELONGATION CC FACTOR 1. CC -!- SIMILARITY: BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASES. CC -!- SIMILARITY: THE N-TERMINAL DOMAIN IS SIMILAR TO ELONGATION CC FACTOR 1-GAMMA. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X59303; G31545; -. DR EMBL; M98326; G1061310; -. DR PIR; S17675; S17675. DR MIM; 192150; 11TH EDITION. DR PROSITE; PS00178; AA_TRNA_LIGASE_I. KW AMINOACYL-TRNA SYNTHASE; PROTEIN BIOSYNTHESIS; LIGASE; ATP-BINDING; KW PHOSPHORYLATION. FT DOMAIN 1 ?200 EF-1-GAMMA LIKE. FT SIMILAR 344 354 "HIGH" REGION. FT SIMILAR 862 864 "KMSKS" REGION. FT BINDING 865 865 ATP (BY SIMILARITY). FT CONFLICT 331 331 G -> A (IN REF. 1). FT CONFLICT 590 590 V -> G (IN REF. 1). FT CONFLICT 620 640 ALINVPPPFLGLPRFEARKAV -> FT GPHQCASAFPGPAQVLRPGKRC (IN REF. 1). FT CONFLICT 792 792 S -> F (IN REF. 1). FT CONFLICT 1064 1064 I -> M (IN REF. 1). FT CONFLICT 1168 1168 L -> LG (IN REF. 1). SQ SEQUENCE 1263 AA; 140376 MW; 018E21E9 CRC32; MSTLYVSPHP DAFPSLRALI AARYGEAGEG PGWGGAHPRI CLQPPPTSRT SFPPPRLPAL EQGPGGLWVW GATAVAQLLW PAGLGGPGGS RAAVLVQQWV SYADTELIPA ACGATLPALG LRSSAQDPQA VLGALGRALS PLEEWLRLHT YLAGEAPTLA DLAAVTALLL PFRYVLDPPA RRIWNNVTRW FVTCVRQPEF RAVLGEVVLY SGARPLSHQP GPEAPALPKT AAQLKKEAKK REKLEKFQQK QKIQQQQPPP GEKKPKPEKR EKRDPGVITY DLPTPPGEKK DVSGPMPDSY SPRYVEAAWY PWWEQQGFFK PEYGRPNVSA GNPRGVFMMC IPPPNVTGSL HLGHALTNAI QDSLTRWHRM RGETTLWNPG CDHAGIATQV VVEKKLWREQ GLSRHQLGRE AFLQEVWKWK EEKGDRIYHQ LKKLGSSLDW DRACFTMDPK LSAAVTEAFV RLHEEGIIYR STRLVNWSCT LNSAISDIEV DKKELTGRTL LSVPGYKEKV EFGVLVSFAY KVQGSDSDEE VVVATTRIET MLGDVAVAVH PKDTRYQHLK GKNVIHPFLS RSLPIVFDEF VDMDFGTGAV KITPAHDQND YEVGQRHGLE AISIMDSRGA LINVPPPFLG LPRFEARKAV LVALKERGLF RGIEDNPMVV PLCNRSKDVV EPLLRPQWYV RCGEMAQAAS AAVTRGDLRI LPEAHQRTWH AWMDNIREWC ISRQLWWGHR IPAYFVTVSD PAVPPGEDPD GRYWVSGRNE AEAREKAAKE FGVSPDKISL QQDEDVLDTW FSSGLFPLSI LGWPNQSEDL SVFYPGTLLE TGHDILFFWV ARMVMLGLKL TGRLPFREVY LHAIVRDAHG RKMSKSLGNV IDPLDVIYGI SLQGLHNQLL NSNLDPSEVE KAKEGQKADF PAGIPECGTD ALRFGLCAYM SQGRDINLDV NRILGYRHFC NKLWNATKFA LRGLGKGFVP SPTSQPGGHE SLVDRWIRSR LTEAVRLSNQ GFQAYDFPAV TTAQYSFWLY ELCDVYLECL KPVLNGVDQV AAECARQTLY TCLDVGLRLL SPFIPFVTEE LFQRLPRRMP QAPPSLCVTP YPEPSECSWK DPEAEAALEL ALSITRAVRS LRADYNLTRI RPDCFLEVAD EATGALASAV SGYVQALASA GVVAVLALAP APQGCAVALA SDRCSIHLQL QGLVDPAREL GKLQAKRVEA QRQAQRLRER RAASGYPVKV PLEVQEADEA KLQQTEAELR KVDEAIALFQ KML //