ID SYV_HUMAN STANDARD; PRT; 1251 AA. AC P26640; DT 01-AUG-1992 (REL. 23, CREATED) DT 01-JUN-1994 (REL. 29, LAST SEQUENCE UPDATE) DT 01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE) DE VALYL-TRNA SYNTHETASE (EC 6.1.1.9) (VALINE--TRNA LIGASE) (VALRS). GN VARS1 OR VARS. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RM 91378943 RA HSIEH H.-L., CAMPBELL R.D.; RL BIOCHEM. J. 278:809-816(1991). RN [2] RP SEQUENCE OF 201-1251 FROM N.A. RM 93154582 RA VILALTA A., DONOVAN D., WOOD L., VOGELI G., YANG D.C.H.; RL GENE 123:181-186(1993). CC -!- CATALYTIC ACTIVITY: ATP + L-VALINE + TRNA(VAL) = AMP + CC PYROPHOSPHATE + L-VALYL-TRNA(VAL). CC -!- ENZYME REGULATION: CAN BE REGULATED BY PROTEIN KINASE C-DEPENDENT CC PHOSPHORYLATION. CC -!- SUBUNIT: FORMS HIGH-MOLECULAR-MASS AGGREGATES WITH ELONGATION CC FACTOR 1. CC -!- SIMILARITY: BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASES. CC -!- SIMILARITY: THE N-TERMINAL DOMAIN IS SIMILAR TO ELONGATION CC FACTOR 1-GAMMA. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X59303; HSG7A. DR EMBL; M98326; HSVALTRSY. DR PIR; S17675; S17675. DR MIM; 192150; 11TH EDITION. DR PROSITE; PS00178; AA_TRNA_LIGASE_I. KW AMINOACYL-TRNA SYNTHASE; PROTEIN BIOSYNTHESIS; LIGASE; ATP-BINDING; KW PHOSPHORYLATION. FT DOMAIN 1 ?200 EF-1-GAMMA LIKE. FT SIMILAR 343 353 "HIGH" REGION. FT SIMILAR 860 864 "KMSKS" REGION. FT BINDING 863 863 ATP (BY SIMILARITY). FT CONFLICT 285 285 H -> P (IN REF. 1). FT CONFLICT 325 330 LLMCQQ -> RPNVSAA (IN REF. 1). FT CONFLICT 398 399 DE -> EQ (IN REF. 1). FT CONFLICT 407 407 V -> GR (IN REF. 1). FT CONFLICT 515 515 P -> S (IN REF. 1). FT CONFLICT 588 588 V -> G (IN REF. 1). FT CONFLICT 618 638 ALINVPPPFLGLPRFEARKAV -> FT GPHQCASAFPGPAQVLRPGKRC (IN REF. 1). FT CONFLICT 790 790 S -> F (IN REF. 1). FT CONFLICT 882 883 RN -> G (IN REF. 1). FT CONFLICT 901 911 PKKRDRKLTPS -> AKEGQKADFPS (IN REF. 1). FT CONFLICT 968 968 L -> V (IN REF. 1). FT CONFLICT 1012 1012 S -> A (IN REF. 1). FT CONFLICT 1016 1016 L -> F (IN REF. 1). FT CONFLICT 1055 1056 AV -> GL (IN REF. 1). FT CONFLICT 1061 1063 TFI -> PFM (IN REF. 1). FT CONFLICT 1108 1109 DV -> EL (IN REF. 1). FT CONFLICT 1118 1118 A -> RS (IN REF. 1). FT CONFLICT 1141 1169 HGRPWHRRCRATCSPGQLQVWWLFWPRSR -> FT TGALASAVSGYVQALASAGVVAVLALGAPA FT (IN REF. 1). FT CONFLICT 1173 1174 SH -> CA (IN REF. 1). FT CONFLICT 1218 1218 P -> R (IN REF. 1). FT CONFLICT 1248 1251 SEGG -> RKVDEAIALFQKML (IN REF. 1). SQ SEQUENCE 1251 AA; 140251 MW; 7834306 CN; MSTLYVSPHP DAFPSLRALI AARYGEAGEG PGWGGAHPRI CLQPPPTSRT SFPPPRLPAL EQGPGGLWVW GATAVAQLLW PAGLGGPGGS RAAVLVQQWV SYADTELIPA ACGATLPALG LRSSAQDPQA VLGALGRALS PLEEWLRLHT YLAGEAPTLA DLAAVTALLL PFRYVLDPPA RRIWNNVTRW FVTCVRQPEF RAVLGEVVLY SGARPLSHQP GPEAPALPKT AAQLKKEAKK REKLEKFQQK QKIQQQQPPP GEKKPKPEKR EKRDPGVITY DLPTHPGEKK DVSGPMPDSY SPRYVEAAWY PWWEQQGFFK PEYGLLMCQQ NPRGVFMMCI PPPNVTGSLH LGHALTNAIQ DSLTRWHRMR GETTLWNPGC DHAGIATQVV VEKKLWRDEG LSRHQLVEAF LQEVWKWKEE KGDRIYHQLK KLGSSLDWDR ACFTMDPKLS AAVTEAFVRL HEEGIIYRST RLVNWSCTLN SAISDIEVDK KELTGRTLLS VPGYKEKVEF GVLVPFAYKV QGSDSDEEVV VATTRIETML GDVAVAVHPK DTRYQHLKGK NVIHPFLSRS LPIVFDEFVD MDFGTGAVKI TPAHDQNDYE VGQRHGLEAI SIMDSRGALI NVPPPFLGLP RFEARKAVLV ALKERGLFRG IEDNPMVVPL CNRSKDVVEP LLRPQWYVRC GEMAQAASAA VTRGDLRILP EAHQRTWHAW MDNIREWCIS RQLWWGHRIP AYFVTVSDPA VPPGEDPDGR YWVSGRNEAE AREKAAKEFG VSPDKISLQQ DEDVLDTWFS SGLFPLSILG WPNQSEDLSV FYPGTLLETG HDILFFWVAR MVMLGLKLTG RLPFREVYLH AIVRDAHGRK MSKSLGNVID PLDVIYGISL QRNLHNQLLN SNLDPSEVEK PKKRDRKLTP SGIPECGTDA LRFGLCAYMS QGRDINLDVN RILGYRHFCN KLWNATKFAL RGLGKGFLPS PTSQPGGHES LVDRWIRSRL TEAVRLSNQG FQAYDFPAVT TSQYSLWLYE LCDVYLECLK PVLNGVDQVA AECARQTLYT CLDVAVRLLS TFIPFVTEEL FQRLPRRMPQ APPSLCVTPY PEPSECSWKD PEAEAALDVA LSITRAVALR ADYNLTRIRP DCFLEVADEA HGRPWHRRCR ATCSPGQLQV WWLFWPRSRP QGSHVALASD RCSIHLQLQG LVDPARELGK LQAKRVEAQR QAQRLREPRA ASGYPVKVPL EVQEADEAKL QQTEAELSEG G //