ID SYV_HUMAN STANDARD; PRT; 1265 AA. AC P26640; DT 01-AUG-1992 (REL. 23, CREATED) DT 01-AUG-1992 (REL. 23, LAST SEQUENCE UPDATE) DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE) DE VALYL-TRNA SYNTHETASE (EC 6.1.1.9) (VALINE--TRNA LIGASE) (VALRS). GN VARS OR G7A. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RM 91378943 RA HSIEH H.-L., CAMPBELL R.D.; RL BIOCHEM. J. 278:809-816(1991). CC -!- CATALYTIC ACTIVITY: ATP + L-VALINE + TRNA(VAL) = AMP + CC PYROPHOSPHATE + L-VALYL-TRNA(VAL). CC -!- SUBUNIT: FORMS HIGH-MOLECULAR-MASS AGGREGATES WITH ELONGATION CC FACTOR 1. CC -!- SIMILARITY: BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASES. CC -!- SIMILARITY: THE N-TERMINAL DOMAIN IS SIMILAR TO ELONGATION CC FACTOR 1-GAMMA. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X59303; HSG7A. DR PIR; S17675; S17675. DR MIM; 192150; TENTH EDITION. DR PROSITE; PS00178; AA_TRNA_LIGASE_I. KW AMINOACYL-TRNA SYNTHASE; PROTEIN BIOSYNTHESIS; LIGASE; ATP-BINDING. FT DOMAIN 1 ?200 EF-1-GAMMA LIKE. FT SIMILAR 344 354 "HIGH" REGION. FT SIMILAR 863 867 "KMSKS" REGION. FT BINDING 866 866 ATP (BY SIMILARITY). SQ SEQUENCE 1265 AA; 140455 MW; 7886217 CN; MSTLYVSPHP DAFPSLRALI AARYGEAGEG PGWGGAHPRI CLQPPPTSRT SFPPPRLPAL EQGPGGLWVW GATAVAQLLW PAGLGGPGGS RAAVLVQQWV SYADTELIPA ACGATLPALG LRSSAQDPQA VLGALGRALS PLEEWLRLHT YLAGEAPTLA DLAAVTALLL PFRYVLDPPA RRIWNNVTRW FVTCVRQPEF RAVLGEVVLY SGARPLSHQP GPEAPALPKT AAQLKKEAKK REKLEKFQQK QKIQQQQPPP GEKKPKPEKR EKRDPGVITY DLPTPPGEKK DVSGPMPDSY SPRYVEAAWY PWWEQQGFFK PEYGRPNVSA ANPRGVFMMC IPPPNVTGSL HLGHALTNAI QDSLTRWHRM RGETTLWNPG CDHAGIATQV VVEKKLWREQ GLSRHQLGRE AFLQEVWKWK EEKGDRIYHQ LKKLGSSLDW DRACFTMDPK LSAAVTEAFV RLHEEGIIYR STRLVNWSCT LNSAISDIEV DKKELTGRTL LSVPGYKEKV EFGVLVSFAY KVQGSDSDEE VVVATTRIET MLGDVAVAVH PKDTRYQHLK GKNVIHPFLS RSLPIVFDEF VDMDFGTGAG KITPAHDQND YEVGQRHGLE AISIMDSRGG PHQCASAFPG PAQVLRPGKR CLVALKERGL FRGIEDNPMV VPLCNRSKDV VEPLLRPQWY VRCGEMAQAA SAAVTRGDLR ILPEAHQRTW HAWMDNIREW CISRQLWWGH RIPAYFVTVS DPAVPPGEDP DGRYWVSGRN EAEAREKAAK EFGVSPDKIS LQQDEDVLDT WFFSGLFPLS ILGWPNQSED LSVFYPGTLL ETGHDILFFW VARMVMLGLK LTGRLPFREV YLHAIVRDAH GRKMSKSLGN VIDPLDVIYG ISLQGLHNQL LNSNLDPSEV EKAKEGQKAD FPAGIPECGT DALRFGLCAY MSQGRDINLD VNRILGYRHF CNKLWNATKF ALRGLGKGFV PSPTSQPGGH ESLVDRWIRS RLTEAVRLSN QGFQAYDFPA VTTAQYSFWL YELCDVYLEC LKPVLNGVDQ VAAECARQTL YTCLDVGLRL LSPFMPFVTE ELFQRLPRRM PQAPPSLCVT PYPEPSECSW KDPEAEAALE LALSITRAVR SLRADYNLTR IRPDCFLEVA DEATGALASA VSGYVQALAS AGVVAVLALG APAPQGCAVA LASDRCSIHL QLQGLVDPAR ELGKLQAKRV EAQRQAQRLR ERRAASGYPV KVPLEVQEAD EAKLQQTEAE LRKVDEAIAL FQKML //