ID SYV_HUMAN STANDARD; PRT; 1263 AA. AC P26640; DT 01-AUG-1992 (Rel. 23, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 01-FEB-1996 (Rel. 33, Last annotation update) DE VALYL-TRNA SYNTHETASE (EC 6.1.1.9) (VALINE--TRNA LIGASE) (VALRS). GN VARS1 OR VARS. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 91378943. RA HSIEH H.-L., CAMPBELL R.D.; RT "Evidence that gene G7a in the human major histocompatibility complex RT encodes valyl-tRNA synthetase."; RL Biochem. J. 278:809-816(1991). RN [2] RP SEQUENCE OF 201-1263 FROM N.A. RX MEDLINE; 93154582. RA VILALTA A., DONOVAN D., WOOD L., VOGELI G., YANG D.C.H.; RT "Cloning, sequencing and expression of a cDNA encoding mammalian RT valyl-tRNA synthetase."; RL Gene 123:181-186(1993). CC -!- CATALYTIC ACTIVITY: ATP + L-VALINE + TRNA(VAL) = AMP + CC PYROPHOSPHATE + L-VALYL-TRNA(VAL). CC -!- ENZYME REGULATION: CAN BE REGULATED BY PROTEIN KINASE C-DEPENDENT CC PHOSPHORYLATION. CC -!- SUBUNIT: FORMS HIGH-MOLECULAR-MASS AGGREGATES WITH ELONGATION CC FACTOR 1. CC -!- SIMILARITY: BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. CC -!- SIMILARITY: THE N-TERMINAL DOMAIN IS SIMILAR TO ELONGATION CC FACTOR 1-GAMMA. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X59303; CAA41990.1; -. DR EMBL; M98326; AAA81332.1; -. DR PIR; S17675; S17675. DR MIM; 192150; -. DR PFAM; PF00043; GST; 1. DR PFAM; PF00133; tRNA-synt_1; 1. DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1. KW Aminoacyl-tRNA synthetase; Protein biosynthesis; Ligase; ATP-binding; KW Phosphorylation. FT DOMAIN 1 ?200 EF-1-GAMMA LIKE. FT SIMILAR 344 354 "HIGH" REGION. FT SIMILAR 862 864 "KMSKS" REGION. FT BINDING 865 865 ATP (BY SIMILARITY). FT CONFLICT 331 331 G -> A (IN REF. 1). FT CONFLICT 590 590 V -> G (IN REF. 1). FT CONFLICT 620 640 ALINVPPPFLGLPRFEARKAV -> FT GPHQCASAFPGPAQVLRPGKRC (IN REF. 1). FT CONFLICT 792 792 S -> F (IN REF. 1). FT CONFLICT 1064 1064 I -> M (IN REF. 1). FT CONFLICT 1168 1168 L -> LG (IN REF. 1). SQ SEQUENCE 1263 AA; 140376 MW; 018E21E9 CRC32; MSTLYVSPHP DAFPSLRALI AARYGEAGEG PGWGGAHPRI CLQPPPTSRT SFPPPRLPAL EQGPGGLWVW GATAVAQLLW PAGLGGPGGS RAAVLVQQWV SYADTELIPA ACGATLPALG LRSSAQDPQA VLGALGRALS PLEEWLRLHT YLAGEAPTLA DLAAVTALLL PFRYVLDPPA RRIWNNVTRW FVTCVRQPEF RAVLGEVVLY SGARPLSHQP GPEAPALPKT AAQLKKEAKK REKLEKFQQK QKIQQQQPPP GEKKPKPEKR EKRDPGVITY DLPTPPGEKK DVSGPMPDSY SPRYVEAAWY PWWEQQGFFK PEYGRPNVSA GNPRGVFMMC IPPPNVTGSL HLGHALTNAI QDSLTRWHRM RGETTLWNPG CDHAGIATQV VVEKKLWREQ GLSRHQLGRE AFLQEVWKWK EEKGDRIYHQ LKKLGSSLDW DRACFTMDPK LSAAVTEAFV RLHEEGIIYR STRLVNWSCT LNSAISDIEV DKKELTGRTL LSVPGYKEKV EFGVLVSFAY KVQGSDSDEE VVVATTRIET MLGDVAVAVH PKDTRYQHLK GKNVIHPFLS RSLPIVFDEF VDMDFGTGAV KITPAHDQND YEVGQRHGLE AISIMDSRGA LINVPPPFLG LPRFEARKAV LVALKERGLF RGIEDNPMVV PLCNRSKDVV EPLLRPQWYV RCGEMAQAAS AAVTRGDLRI LPEAHQRTWH AWMDNIREWC ISRQLWWGHR IPAYFVTVSD PAVPPGEDPD GRYWVSGRNE AEAREKAAKE FGVSPDKISL QQDEDVLDTW FSSGLFPLSI LGWPNQSEDL SVFYPGTLLE TGHDILFFWV ARMVMLGLKL TGRLPFREVY LHAIVRDAHG RKMSKSLGNV IDPLDVIYGI SLQGLHNQLL NSNLDPSEVE KAKEGQKADF PAGIPECGTD ALRFGLCAYM SQGRDINLDV NRILGYRHFC NKLWNATKFA LRGLGKGFVP SPTSQPGGHE SLVDRWIRSR LTEAVRLSNQ GFQAYDFPAV TTAQYSFWLY ELCDVYLECL KPVLNGVDQV AAECARQTLY TCLDVGLRLL SPFIPFVTEE LFQRLPRRMP QAPPSLCVTP YPEPSECSWK DPEAEAALEL ALSITRAVRS LRADYNLTRI RPDCFLEVAD EATGALASAV SGYVQALASA GVVAVLALAP APQGCAVALA SDRCSIHLQL QGLVDPAREL GKLQAKRVEA QRQAQRLRER RAASGYPVKV PLEVQEADEA KLQQTEAELR KVDEAIALFQ KML //