ID VE6_HPV58 Reviewed; 149 AA. AC P26555; DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1992, sequence version 1. DT 08-FEB-2011, entry version 56. DE RecName: Full=Protein E6; GN Name=E6; OS Human papillomavirus type 58. OC Viruses; dsDNA viruses, no RNA stage; Papillomaviridae; OC Alphapapillomavirus. OX NCBI_TaxID=10598; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=92024102; PubMed=1656594; DOI=10.1016/0042-6822(91)90791-9; RA Kirii Y., Iwamoto S., Matsukura T.; RT "Human papillomavirus type 58 DNA sequence."; RL Virology 185:424-427(1991). CC -!- FUNCTION: Transcriptional transactivator. Binds double stranded CC DNA (By similarity). CC -!- SUBCELLULAR LOCATION: Host nucleus matrix (By similarity). CC -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D90400; BAA31845.1; -; Genomic_DNA. DR PIR; E36779; W6WL58. DR ProteinModelPortal; P26555; -. DR SMR; P26555; 80-144. DR GO; GO:0044204; C:host cell nuclear matrix; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW. DR GO; GO:0006350; P:transcription; IEA:UniProtKB-KW. DR InterPro; IPR001334; E6. DR Pfam; PF00518; E6; 1. PE 3: Inferred from homology; KW Activator; Complete proteome; DNA-binding; Early protein; KW Host nucleus; Host-virus interaction; KW Inhibition of host IFN-mediated response initiation by virus; KW Inhibition of host innate immune response by virus; KW Inhibition of host IRF3 by virus; Metal-binding; Transcription; KW Transcription regulation; Viral immunoevasion; Zinc; Zinc-finger. FT CHAIN 1 149 Protein E6. FT /FTId=PRO_0000133374. FT ZN_FING 30 66 Potential. FT ZN_FING 103 139 Potential. SQ SEQUENCE 149 AA; 17794 MW; 79B3DCC95831B158 CRC64; MFQDAEEKPR TLHDLCQALE TSVHEIELKC VECKKTLQRS EVYDFVFADL RIVYRDGNPF AVCKVCLRLL SKISEYRHYN YSLYGDTLEQ TLKKCLNEIL IRCIICQRPL CPQEKKRHVD LNKRFHNISG RWTGRCAVCW RPRRRQTQV //