ID KAPA_CRIGR STANDARD; PRT; 350 AA. AC P25321; DT 01-MAY-1992 (REL. 22, CREATED) DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT (EC 2.7.1.37) DE (PKA C-ALPHA). OS CRICETULUS GRISEUS (CHINESE HAMSTER). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 91244783. RA HOWARD P., DAY K.H., KIM K.E., RICHARDSON J., THOMAS J., ABRAHAM I., RA FLEISCHMANN R.D., GOTTESMAN M.M., MAURER R.A.; RL J. BIOL. CHEM. 266:10189-10195(1991). CC -!- CATALYTIC ACTIVITY: ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN. CC -!- SUBUNIT: COMPOSED OF TWO REGULATORY CHAINS AND TWO CATALYTIC CC CHAINS. CC -!- ENZYME REGULATION: THIS ENZYME IS ACTIVATED BY CAMP. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M63311; M63311. DR PIR; B40384; OKHYCA. DR HSSP; P05132; 1CTP. DR PROSITE; PS00107; PROTEIN_KINASE_ATP. DR PROSITE; PS00108; PROTEIN_KINASE_ST. DR PROSITE; PS50011; PROTEIN_KINASE_DOM. KW TRANSFERASE; SERINE/THREONINE-PROTEIN KINASE; ATP-BINDING; CAMP; KW PHOSPHORYLATION; MYRISTYLATION; MULTIGENE FAMILY. FT INIT_MET 0 0 FT LIPID 1 1 MYRISTATE (BY SIMILARITY). FT DOMAIN 43 297 PROTEIN KINASE. FT NP_BIND 49 57 ATP (BY SIMILARITY). FT BINDING 72 72 ATP (BY SIMILARITY). FT ACT_SITE 166 166 BY SIMILARITY. FT MOD_RES 197 197 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 338 338 PHOSPHORYLATION (BY SIMILARITY). SQ SEQUENCE 350 AA; 40488 MW; 642030 CN; GNAAAAKKGS EQESVKEFLA KAKEEFLKKW ESPSQNTAQL DHFDRIKTLG TGSFGRVMLV KHKETGNHYA MKILDKQKVV KLKQIEHTLN EKRILQAVNF PFLVKLEFSF KDNSNLYMVM EYVPGGEMFS HLRRIGRFSE PHARFYAAQI VLTFEYLHSL DLIYRDLKPE NLLIDQQGYI QVTDFGFAKR VKGRTWTLCG TPEYLAPEII LSKGYNKAVD WWALGVLIYE MAAGYPPFFA DQPIQIYEKI VSGKVRFPSH FSSDLKDLLR NLLQVDLTKR FGNLKNGVND IKNHKWFATT DWIAIYQRKV EAPFIPKFKG PGDTSNFDDY EEEEIRVSIN EKCGKEFTEF //