ID LASR_PSEAE STANDARD; PRT; 239 AA. AC P25084; Q51475; Q51476; DT 01-MAY-1992 (Rel. 22, Created) DT 01-MAY-1992 (Rel. 22, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE LASR REGULATORY PROTEIN. GN LASR. OS Pseudomonas aeruginosa. OC Bacteria; Proteobacteria; gamma subdivision; Pseudomonas group; OC Pseudomonas. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=ATCC 15692 / PAO1; RX MEDLINE; 91210193. RA GAMBELLO M.J., IGLEWSKI B.H.; RT "Cloning and characterization of the Pseudomonas aeruginosa lasR RT gene, a transcriptional activator of elastase expression."; RL J. Bacteriol. 173:3000-3009(1991). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=PA103, AND IFO 3455; RX MEDLINE; 95023115. RA FUKUSHIMA J., ISHIWATA T., KURATA M., YOU Z., OKUDA K.; RT "Intracellular receptor-type transcription factor, LasR, contains a RT highly conserved amphipathic region which precedes the putative RT helix-turn-helix DNA binding motif."; RL Nucleic Acids Res. 22:3706-3707(1994). CC -!- FUNCTION: TRANSCRIPTIONAL ACTIVATOR OF ELASTASE STRUCTURAL GENE CC (LASB). BINDS TO THE PAI AUTOINDUCER. CC -!- MISCELLANEOUS: LASR IN STRAIN PA103 IS NOT ACTIVE, THIS IS CC PROBABLY DUE TO THE CHANGE IN POSITION 180 OF THE SEQUENCE. CC -!- SIMILARITY: BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL CC REGULATORS. AUTOINDUCER REGULATED SUBFAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M59425; AAA25874.1; -. DR EMBL; D30813; BAA06490.1; -. DR EMBL; D30812; BAA06489.1; -. DR PIR; A43660; A43660. DR PFAM; PF00196; GerE; 1. DR PROSITE; PS00622; HTH_LUXR_FAMILY; 1. KW Transcription regulation; DNA-binding; Activator; KW Autoinducer induction. FT DNA_BIND 194 213 H-T-H MOTIF (BY SIMILARITY). FT VARIANT 144 144 M -> I (IN STRAINS IFO 3455 AND PA103). FT VARIANT 180 180 R -> W (IN STRAIN PA103). SQ SEQUENCE 239 AA; 26618 MW; CC6B1BDD CRC32; MALVDGFLEL ERSSGKLEWS AILQKMASDL GFSKILFGLL PKDSQDYENA FIVGNYPAAW REHYDRAGYA RVDPTVSHCT QSVLPIFWEP SIYQTRKQHE FFEEASAAGL VYGLTMPLHG ARGELGALSL SVEAENRAEA NRFMESVLPT LWMLKDYALQ SGAGLAFEHP VSKPVVLTSR EKEVLQWCAI GKTSWEISVI CNCSEANVNF HMGNIRRKFG VTSRRVAAIM AVNLGLITL //