ID LASR_PSEAE STANDARD; PRT; 239 AA. AC P25084; Q51475; Q51476; DT 01-MAY-1992 (Rel. 22, Created) DT 01-MAY-1992 (Rel. 22, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE TRANSCRIPTIONAL ACTIVATOR PROTEIN LASR. GN LASR. OS Pseudomonas aeruginosa. OC Bacteria; Proteobacteria; gamma subdivision; Pseudomonadaceae; OC Pseudomonas. OX NCBI_TaxID=287; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=ATCC 15692 / PAO1; RX MEDLINE=91210193; PubMed=1902216; RA Gambello M.J., Iglewski B.H.; RT "Cloning and characterization of the Pseudomonas aeruginosa lasR RT gene, a transcriptional activator of elastase expression."; RL J. Bacteriol. 173:3000-3009(1991). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=PA103, AND IFO 3455; RX MEDLINE=95023115; PubMed=7937080; RA Fukushima J., Ishiwata T., Kurata M., You Z., Okuda K.; RT "Intracellular receptor-type transcription factor, LasR, contains a RT highly conserved amphipathic region which precedes the putative RT helix-turn-helix DNA binding motif."; RL Nucleic Acids Res. 22:3706-3707(1994). CC -!- FUNCTION: TRANSCRIPTIONAL ACTIVATOR OF ELASTASE STRUCTURAL GENE CC (LASB). BINDS TO THE PAI AUTOINDUCER. CC -!- MISCELLANEOUS: LASR IN STRAIN PA103 IS NOT ACTIVE, THIS IS CC PROBABLY DUE TO THE CHANGE IN POSITION 180 OF THE SEQUENCE. CC -!- SIMILARITY: BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL CC REGULATORS. AUTOINDUCER REGULATED SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M59425; AAA25874.1; -. DR EMBL; D30813; BAA06490.1; -. DR EMBL; D30812; BAA06489.1; -. DR PIR; A43660; A43660. DR INTERPRO; IPR000792; -. DR PFAM; PF00196; GerE; 1. DR PROSITE; PS00622; HTH_LUXR_FAMILY; 1. KW Transcription regulation; DNA-binding; Activator; KW Quorum sensing; Autoinducer synthesis. FT DNA_BIND 194 213 H-T-H MOTIF (BY SIMILARITY). FT VARIANT 144 144 M -> I (IN STRAINS IFO 3455 AND PA103). FT VARIANT 180 180 R -> W (IN STRAIN PA103). SQ SEQUENCE 239 AA; 26618 MW; 28B6E06E9187924A CRC64; MALVDGFLEL ERSSGKLEWS AILQKMASDL GFSKILFGLL PKDSQDYENA FIVGNYPAAW REHYDRAGYA RVDPTVSHCT QSVLPIFWEP SIYQTRKQHE FFEEASAAGL VYGLTMPLHG ARGELGALSL SVEAENRAEA NRFMESVLPT LWMLKDYALQ SGAGLAFEHP VSKPVVLTSR EKEVLQWCAI GKTSWEISVI CNCSEANVNF HMGNIRRKFG VTSRRVAAIM AVNLGLITL //