ID NU4LM_CAEEL Reviewed; 77 AA. AC P24886; DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot. DT 11-APR-2003, sequence version 2. DT 05-JUL-2017, entry version 99. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L; DE EC=1.6.5.3; DE AltName: Full=NADH dehydrogenase subunit 4L; GN Name=ndfl-4 {ECO:0000312|WormBase:MTCE.4}; GN Synonyms=nd4l {ECO:0000312|WormBase:MTCE.4}; GN ORFNames=MTCE.4 {ECO:0000312|WormBase:MTCE.4}; OS Caenorhabditis elegans. OG Mitochondrion. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-41 AND LEU-70. RC STRAIN=AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, RC CB4857, CB4858, KR314, PB303, PB306, RW7000, and TR403; RX PubMed=12644560; DOI=10.1093/molbev/msg044; RA Denver D.R., Morris K., Thomas W.K.; RT "Phylogenetics in Caenorhabditis elegans: an analysis of divergence RT and outcrossing."; RL Mol. Biol. Evol. 20:393-400(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX PubMed=1551572; RA Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.; RT "The mitochondrial genomes of two nematodes, Caenorhabditis elegans RT and Ascaris suum."; RL Genetics 130:471-498(1992). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi- CC pass membrane protein {ECO:0000250}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY171133; AAO16386.1; -; Genomic_DNA. DR EMBL; AY171134; AAO16389.1; -; Genomic_DNA. DR EMBL; AY171135; AAO16392.1; -; Genomic_DNA. DR EMBL; AY171136; AAO16395.1; -; Genomic_DNA. DR EMBL; AY171137; AAO16398.1; -; Genomic_DNA. DR EMBL; AY171138; AAO16401.1; -; Genomic_DNA. DR EMBL; AY171139; AAO16404.1; -; Genomic_DNA. DR EMBL; AY171140; AAO16407.1; -; Genomic_DNA. DR EMBL; AY171141; AAO16410.1; -; Genomic_DNA. DR EMBL; AY171142; AAO16413.1; -; Genomic_DNA. DR EMBL; AY171143; AAO16416.1; -; Genomic_DNA. DR EMBL; AY171144; AAO16419.1; -; Genomic_DNA. DR EMBL; AY171145; AAO16422.1; -; Genomic_DNA. DR EMBL; AY171146; AAO16425.1; -; Genomic_DNA. DR EMBL; AY171147; AAO16428.1; -; Genomic_DNA. DR EMBL; X54252; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PIR; S26027; S26027. DR RefSeq; NP_006954.1; NC_001328.1. DR STRING; 6239.MTCE.4; -. DR PaxDb; P24886; -. DR PRIDE; P24886; -. DR GeneID; 2565694; -. DR KEGG; cel:ND4L; -. DR CTD; 4539; -. DR WormBase; MTCE.4; CE35354; WBGene00010958; ndfl-4. DR InParanoid; P24886; -. DR KO; K03882; -. DR OrthoDB; EOG091G0ZRL; -. DR PRO; PR:P24886; -. DR Proteomes; UP000001940; Mitochondrion. DR Bgee; WBGene00010958; -. DR ExpressionAtlas; P24886; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:WormBase. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB. PE 3: Inferred from homology; KW Complete proteome; Electron transport; Membrane; Mitochondrion; NAD; KW Oxidoreductase; Polymorphism; Reference proteome; Respiratory chain; KW Transmembrane; Transmembrane helix; Transport; Ubiquinone. FT CHAIN 1 77 NADH-ubiquinone oxidoreductase chain 4L. FT /FTId=PRO_0000118401. FT TRANSMEM 15 37 Helical. {ECO:0000255}. FT TRANSMEM 44 64 Helical. {ECO:0000255}. FT VARIANT 41 41 G -> S (in strain: PB303). FT {ECO:0000269|PubMed:12644560}. FT VARIANT 70 70 F -> L (in strain: CB4855). FT {ECO:0000269|PubMed:12644560}. SQ SEQUENCE 77 AA; 9249 MW; F123ECE07D07A829 CRC64; MMFLFVSLFM FIFKWQRLIF ILISLEFMML SLFLKFSYVL GEMMFFYFMC FSVISSILGM VVMVGNMKFF GSDNCIF //