ID NU4LM_CAEEL Reviewed; 77 AA. AC P24886; DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot. DT 11-APR-2003, sequence version 2. DT 25-MAY-2022, entry version 114. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L; DE EC=7.1.1.2; DE AltName: Full=NADH dehydrogenase subunit 4L; GN Name=ndfl-4 {ECO:0000312|WormBase:MTCE.4}; GN Synonyms=nd4l {ECO:0000312|WormBase:MTCE.4}; GN ORFNames=MTCE.4 {ECO:0000312|WormBase:MTCE.4}; OS Caenorhabditis elegans. OG Mitochondrion. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-41 AND LEU-70. RC STRAIN=AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, RC CB4857, CB4858, KR314, PB303, PB306, RW7000, and TR403; RX PubMed=12644560; DOI=10.1093/molbev/msg044; RA Denver D.R., Morris K., Thomas W.K.; RT "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and RT outcrossing."; RL Mol. Biol. Evol. 20:393-400(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX PubMed=1551572; DOI=10.1093/genetics/130.3.471; RA Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.; RT "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and RT Ascaris suum."; RL Genetics 130:471-498(1992). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone (By CC similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass CC membrane protein {ECO:0000250}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY171133; AAO16386.1; -; Genomic_DNA. DR EMBL; AY171134; AAO16389.1; -; Genomic_DNA. DR EMBL; AY171135; AAO16392.1; -; Genomic_DNA. DR EMBL; AY171136; AAO16395.1; -; Genomic_DNA. DR EMBL; AY171137; AAO16398.1; -; Genomic_DNA. DR EMBL; AY171138; AAO16401.1; -; Genomic_DNA. DR EMBL; AY171139; AAO16404.1; -; Genomic_DNA. DR EMBL; AY171140; AAO16407.1; -; Genomic_DNA. DR EMBL; AY171141; AAO16410.1; -; Genomic_DNA. DR EMBL; AY171142; AAO16413.1; -; Genomic_DNA. DR EMBL; AY171143; AAO16416.1; -; Genomic_DNA. DR EMBL; AY171144; AAO16419.1; -; Genomic_DNA. DR EMBL; AY171145; AAO16422.1; -; Genomic_DNA. DR EMBL; AY171146; AAO16425.1; -; Genomic_DNA. DR EMBL; AY171147; AAO16428.1; -; Genomic_DNA. DR EMBL; X54252; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PIR; S26027; S26027. DR RefSeq; NP_006954.1; NC_001328.1. DR AlphaFoldDB; P24886; -. DR SMR; P24886; -. DR STRING; 6239.MTCE.4; -. DR EPD; P24886; -. DR PaxDb; P24886; -. DR GeneID; 2565694; -. DR KEGG; cel:ND4L; -. DR CTD; 4539; -. DR WormBase; MTCE.4; CE35354; WBGene00010958; ndfl-4. DR HOGENOM; CLU_2640347_0_0_1; -. DR InParanoid; P24886; -. DR PRO; PR:P24886; -. DR Proteomes; UP000001940; Mitochondrion. DR Bgee; WBGene00010958; Expressed in multi-cellular organism and 3 other tissues. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:WormBase. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome; KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix; KW Transport; Ubiquinone. FT CHAIN 1..77 FT /note="NADH-ubiquinone oxidoreductase chain 4L" FT /id="PRO_0000118401" FT TRANSMEM 15..37 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 44..64 FT /note="Helical" FT /evidence="ECO:0000255" FT VARIANT 41 FT /note="G -> S (in strain: PB303)" FT /evidence="ECO:0000269|PubMed:12644560" FT VARIANT 70 FT /note="F -> L (in strain: CB4855)" FT /evidence="ECO:0000269|PubMed:12644560" SQ SEQUENCE 77 AA; 9249 MW; F123ECE07D07A829 CRC64; MMFLFVSLFM FIFKWQRLIF ILISLEFMML SLFLKFSYVL GEMMFFYFMC FSVISSILGM VVMVGNMKFF GSDNCIF //