ID MINK_MOUSE STANDARD; PRT; 129 AA. AC P23299; DT 01-NOV-1991 (REL. 20, CREATED) DT 01-NOV-1991 (REL. 20, LAST SEQUENCE UPDATE) DT 01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE) DE ISK SLOW VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN (MINK POTASSIUM DE CHANNEL). GN KCNE1. OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC RODENTIA; SCIUROGNATHI; MURIDAE; MURINAE; MUS. RN [1] RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. RC TISSUE=HEART; RX MEDLINE; 92007723. RA HONORE E., ATTALI B., ROMEY G., HEURTEAUX C., RICARD P., LESAGE F., RA LAZDUNSKI M., BARHANIN J.; RT "Cloning, expression, pharmacology and regulation of a delayed RT rectifier K+ channel in mouse heart."; RL EMBO J. 10:2805-2811(1991). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 92233938. RA LESAGE F., ATTALI B., LAZDUNSKI M., BARHANIN J.; RT "ISK, a slowly activating voltage-sensitive K+ channel. RT Characterization of multiple cDNAs and gene organization in the RT mouse."; RL FEBS LETT. 301:168-172(1992). CC -!- FUNCTION: VERY SLOWLY ACTIVATED VOLTAGE-DEPENDENT POTASSIUM CC CHANNEL. THE OUTWARD CURRENT REACHS ITS STEADY STATE ONLY AFTER CC 50 SECONDS. CC -!- SUBUNIT: IT IS NOT YET KNOWN HOW MANY SUBUNITS ARE NECESSARY CC TO FORM A FUNCTIONAL CHANNEL. CC -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: RESTRICTIVELY LOCALIZED IN THE APICAL CC MEMBRANE PORTION OF EPITHELIAL CELLS. CC -!- PTM: PHOSPHORYLATION INHIBITS THE POTASSIUM CURRENT (BY CC SIMILARITY). CC -!- SIMILARITY: WITH THE HUMAN AND RAT COUNTERPARTS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X60457; G52780; -. DR PIR; S17307; S17307. DR PIR; S21135; S21135. DR MGD; MGI:96673; KCNE1. KW IONIC CHANNEL; TRANSMEMBRANE; ION TRANSPORT; VOLTAGE-GATED CHANNEL; KW GLYCOPROTEIN; PHOSPHORYLATION. FT DOMAIN 1 43 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 44 66 POTENTIAL. FT DOMAIN 67 129 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 POTENTIAL. FT CARBOHYD 26 26 POTENTIAL. FT MOD_RES 102 102 PHOSPHORYLATION (BY PKC) (BY SIMILARITY). SQ SEQUENCE 129 AA; 14578 MW; 1A1E7471 CRC32; MSLPNSTTVL PFLARLWQET AEQGGNVSGL ARKSQLRDDS KLEALYILMV LGFFGFFTLG IMLSYIRSKK LEHSHDPFNV YIESDAWQEK GKAVFQARVL ESFRACYVIE NQAAVEQPAT HLPELKPLS //