ID MINK_MOUSE STANDARD; PRT; 129 AA. AC P23299; DT 01-NOV-1991 (Rel. 20, Created) DT 01-NOV-1991 (Rel. 20, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Potassium voltage-gated channel subfamily E member 1 (IKs producing DE slow voltage-gated potassium channel beta subunit Mink) (Minimal DE potassium channel) (Delayed rectifier potassium channel subunit IsK) DE (mISK). GN KCNE1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. RC TISSUE=Heart; RX MEDLINE=92007723; PubMed=1655403; RA Honore E., Attali B., Romey G., Heurteaux C., Ricard P., Lesage F., RA Lazdunski M., Barhanin J.; RT "Cloning, expression, pharmacology and regulation of a delayed RT rectifier K+ channel in mouse heart."; RL EMBO J. 10:2805-2811(1991). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=92233938; PubMed=1568475; RA Lesage F., Attali B., Lazdunski M., Barhanin J.; RT "ISK, a slowly activating voltage-sensitive K+ channel. RT Characterization of multiple cDNAs and gene organization in the RT mouse."; RL FEBS Lett. 301:168-172(1992). CC -!- FUNCTION: Ancillary protein that assembles as a beta subunit with CC a voltage-gated potassium channel complex of pore-forming alpha CC subunits. Modulates the gating kinetics and enhances stability of CC the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to CC form the slowly activating delayed rectifier cardiac potassium CC (IKs) channel. The outward current reaches its steady state only CC after 50 seconds. Assembled with KCNH2/HERG may modulate the CC rapidly activating component of the delayed rectifying potassium CC current in heart (IKr) (By similarity). CC -!- SUBUNIT: Associates with KCNQ1/KVLQT1 and KCNH2/HERG (By CC similarity). CC -!- SUBCELLULAR LOCATION: Type I membrane protein. CC -!- TISSUE SPECIFICITY: Restrictively localized in the apical CC membrane portion of epithelial cells. CC -!- PTM: Phosphorylation inhibits the potassium current (By CC similarity). CC -!- SIMILARITY: Belongs to the potassium channel KCNE family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X60457; CAA42990.1; -. DR PIR; S17307; S17307. DR MGD; MGI:96673; Kcne1. DR InterPro; IPR000369; ISK_Channel. DR InterPro; IPR005424; KCNE_beta1. DR Pfam; PF02060; ISK_Channel; 1. DR PRINTS; PR01604; KCNE1CHANNEL. DR PRINTS; PR00168; KCNECHANNEL. KW Transport; Ion transport; Ionic channel; Voltage-gated channel; KW Potassium channel; Potassium; Potassium transport; Transmembrane; KW Glycoprotein; Phosphorylation. FT TRANSMEM 44 66 POTENTIAL. FT DOMAIN 67 129 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 26 26 N-LINKED (GLCNAC...) (POTENTIAL). FT MOD_RES 102 102 PHOSPHORYLATION (BY PKC) (BY SIMILARITY). SQ SEQUENCE 129 AA; 14578 MW; E66DF4742300E839 CRC64; MSLPNSTTVL PFLARLWQET AEQGGNVSGL ARKSQLRDDS KLEALYILMV LGFFGFFTLG IMLSYIRSKK LEHSHDPFNV YIESDAWQEK GKAVFQARVL ESFRACYVIE NQAAVEQPAT HLPELKPLS //