ID MINK_MOUSE STANDARD; PRT; 129 AA. AC P23299; DT 01-NOV-1991 (Rel. 20, Created) DT 01-NOV-1991 (Rel. 20, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE ISK SLOW VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN (MINIMAL POTASSIUM DE CHANNEL) (MINK). GN KCNE1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. RC TISSUE=HEART; RX MEDLINE=92007723; PubMed=1655403; RA Honore E., Attali B., Romey G., Heurteaux C., Ricard P., Lesage F., RA Lazdunski M., Barhanin J.; RT "Cloning, expression, pharmacology and regulation of a delayed RT rectifier K+ channel in mouse heart."; RL EMBO J. 10:2805-2811(1991). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=92233938; PubMed=1568475; RA Lesage F., Attali B., Lazdunski M., Barhanin J.; RT "ISK, a slowly activating voltage-sensitive K+ channel. RT Characterization of multiple cDNAs and gene organization in the RT mouse."; RL FEBS Lett. 301:168-172(1992). CC -!- FUNCTION: ANCILLARY PROTEIN THAT CO-ASSEMBLE WITH A POTASSIUM CC CHANNEL ALPHA-SUBUNIT TO MODULATE THE GATING KINETICS AND ENHANCE CC STABILITY OF THE MULTIMERIC COMPLEX. KCNE1 CO-ASSEMBLE WITH KCNQ1 CC (KVLQT1) TO FORM THE SLOWLY ACTIVATING DELAYED RECTIFIER CARDIAC CC POTASSIUM (IKS) CHANNEL. THE OUTWARD CURRENT REACHS ITS STEADY CC STATE ONLY AFTER 50 SECONDS (BY SIMILARITY). CC -!- SUBUNIT: ASSOCIATES WITH KCNQ1 (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: RESTRICTIVELY LOCALIZED IN THE APICAL CC MEMBRANE PORTION OF EPITHELIAL CELLS. CC -!- PTM: PHOSPHORYLATION INHIBITS THE POTASSIUM CURRENT (BY CC SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE KCNE FAMILY OF POTASSIUM CHANNELS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X60457; CAA42990.1; -. DR PIR; S17307; S17307. DR PIR; S21135; S21135. DR MGD; MGI:96673; KCNE1. DR INTERPRO; IPR000369; -. DR PFAM; PF02060; ISK_Channel; 1. DR PRINTS; PR00168; ISKCHANNEL. KW Ionic channel; Transmembrane; Ion transport; Voltage-gated channel; KW Glycoprotein; Phosphorylation. FT DOMAIN 1 43 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 44 66 POTENTIAL. FT DOMAIN 67 129 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 5 5 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 26 26 N-LINKED (GLCNAC...) (POTENTIAL). FT MOD_RES 102 102 PHOSPHORYLATION (BY PKC) (BY SIMILARITY). SQ SEQUENCE 129 AA; 14578 MW; E66DF4742300E839 CRC64; MSLPNSTTVL PFLARLWQET AEQGGNVSGL ARKSQLRDDS KLEALYILMV LGFFGFFTLG IMLSYIRSKK LEHSHDPFNV YIESDAWQEK GKAVFQARVL ESFRACYVIE NQAAVEQPAT HLPELKPLS //