ID   INTR_SACER              Reviewed;         437 AA.
AC   P22877;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   16-OCT-2019, entry version 74.
DE   RecName: Full=Integrase;
DE   AltName: Full=Recombinase;
GN   Name=int;
OS   Saccharopolyspora erythraea (Streptomyces erythraeus).
OG   Plasmid pSE211.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=1836;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ER720;
RX   PubMed=2180909; DOI=10.1128/jb.172.4.1877-1888.1990;
RA   Brown D.P., Idler K.B., Katz L.;
RT   "Characterization of the genetic elements required for site-specific
RT   integration of plasmid pSE211 in Saccharopolyspora erythraea.";
RL   J. Bacteriol. 172:1877-1888(1990).
CC   -!- FUNCTION: Is a recombinase (or integrase), catalyzing the cutting
CC       and rejoining of the recombining DNA molecules.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC       {ECO:0000305}.
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DR   EMBL; M35138; AAA98345.1; -; Genomic_DNA.
DR   PIR; C35147; C35147.
DR   eggNOG; ENOG4107T65; Bacteria.
DR   eggNOG; ENOG410XRH6; LUCA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   Pfam; PF14659; Phage_int_SAM_3; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN         1    437       Integrase.
FT                                /FTId=PRO_0000197534.
FT   DOMAIN       73    158       Core-binding (CB). {ECO:0000255|PROSITE-
FT                                ProRule:PRU01248}.
FT   DOMAIN      179    428       Tyr recombinase. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01246}.
FT   ACT_SITE    214    214       {ECO:0000255|PROSITE-ProRule:PRU01246}.
FT   ACT_SITE    245    245       {ECO:0000255|PROSITE-ProRule:PRU01246}.
FT   ACT_SITE    379    379       {ECO:0000255|PROSITE-ProRule:PRU01246}.
FT   ACT_SITE    382    382       {ECO:0000255|PROSITE-ProRule:PRU01246}.
FT   ACT_SITE    405    405       {ECO:0000255|PROSITE-ProRule:PRU01246}.
FT   ACT_SITE    414    414       O-(3'-phospho-DNA)-tyrosine intermediate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01246}.
SQ   SEQUENCE   437 AA;  50324 MW;  29EED7108CC5AFBD CRC64;
     MEQKRTRNPN GRSTIYLGND GYWHGRVTMG IGDDGKPDRR HVKRKDKDEV VEEVGKLERE
     RDSGNVRKKG QPWTVERWLT HWVESIAPLT CRYKTMRGYQ TAVYKHLIPG LGAHRLDRIQ
     NHPEYFEKFY LRMIESGLKP ATAHQVHRTA RTAFGEAYKR GRIQRNPVSI AKAPRVEEEE
     VEPLEVEDMQ LVIKAALERR NGVRYVIALA LGTRQGESLA LKWPRLNRQK RTLRITKALQ
     RQTWKHGCSD PHRCGATYHK TEPCKAACKR HTRACPPPCP PACTEHARWC PQRTGGGLVE
     VDVKSRAGRR TVTLPDQLFD LILKHEKLQG AERELAGTEW HDGEWMFTQP NGKPIDPRQD
     LDEWKAILVE AGVREARLHD ARHTAATVLL VLGVPDRVVM ELMGWSSVTM KQRYMHVIDS
     VRNDVADRLN TYFWGTN
//