ID HMN1_DROME STANDARD; PRT; 659 AA. AC P22807; DT 01-AUG-1991 (Rel. 19, Created) DT 01-AUG-1991 (Rel. 19, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Homeobox protein NK-1 (S59/2). GN NK1 OR S59. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=91099659; PubMed=1980118; RA Dohrmann C., Azpiazu N., Frasch M.; RT "A new Drosophila homeo box gene is expressed in mesodermal precursor RT cells of distinct muscles during embryogenesis."; RL Genes Dev. 4:2098-2111(1990). RN [2] RP SEQUENCE OF 497-625 FROM N.A. RX MEDLINE=90046666; PubMed=2573058; RA Kim Y., Nirenberg M.; RT "Drosophila NK-homeobox genes."; RL Proc. Natl. Acad. Sci. U.S.A. 86:7716-7720(1989). CC -!- FUNCTION: MAY PLAY A ROLE IN SPECIFYING THE IDENTITY OF PARTICULAR CC SOMATIC MUSCLES AND NEURONS OF THE CNS. CC -!- SUBCELLULAR LOCATION: Nuclear (Probable). CC -!- TISSUE SPECIFICITY: MESODERMAL PRECURSOR CELLS OF DISTINCT MUSCLES CC DURING EMBRYOGENESIS, A SUBSET OF NEURONAL CELLS OF THE CNS AND CC THEIR PRECURSORS AND ALSO IN CELLS OF A SMALL REGION OF THE CC MIDGUT. CC -!- DEVELOPMENTAL STAGE: POSTGASTRULATION-STAGE. CC -!- SIMILARITY: BELONGS TO THE NK-1 FAMILY OF HOMEOBOX PROTEINS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X55393; CAA39067.1; -. DR EMBL; M27289; AAA28616.1; -. DR PIR; A36664; A36664. DR PIR; A33976; A33976. DR HSSP; P02833; 1SAN. DR FlyBase; FBgn0002941; Nk1. DR InterPro; IPR001356; Homeobox. DR Pfam; PF00046; homeobox; 1. DR PRINTS; PR00024; HOMEOBOX. DR ProDom; PD000010; Homeobox; 1. DR SMART; SM00389; HOX; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. KW Homeobox; DNA-binding; Developmental protein; Nuclear protein; KW Repeat. FT DOMAIN 201 239 HIS-RICH. FT DOMAIN 221 234 7 X 2 AA TANDEM REPEATS OF H-P. FT DOMAIN 364 372 POLY-ALA. FT DOMAIN 477 522 ASP/GLU-RICH (ACIDIC). FT DOMAIN 536 542 POLY-GLY. FT DNA_BIND 545 604 HOMEOBOX. SQ SEQUENCE 659 AA; 69955 MW; 5D401F55C4670280 CRC64; MVMLQSPAQK ASDSASAQNT AVGGLMSPNS NPDSPKSNTS PDVASADSVV SGTGGGSTPP AAKIPKFIIS ANGAAVAGKQ EQELRYSLER LKQMSSESGS LLSRLSPLQE DSQDKEKPNH NNNNSLTNHN ANSNTRRSQS PPASVGSVSF SSPAQQRKLL ELNAVRHLAR PEPLQHPHAA LLQQHPHLLQ NPQFLAAAQQ HMHHHQHQHH QHPAHPHSHQ HPHPHPHPHP HPHPSAVFHL RAPSSSSTAP PSPATSPLSP PTSPAMHSDQ QMSPPIAPPQ NPPHSSQPPQ QQQVAAPSDM DLERIKLVAA VAARTTQASS TSALASASNS VSNASISISN SSSGSPSGRD LSDYGFRIQL GGLAAAAAAA AATSRQIAAA TYARSDTSEE LNVDGNDEDS NDGSHSTPSV CPVDLTRSVN SSAAANPSSA STSASSDRDA ATKRLAFSVE NILDPNKFTG NKLPSGPFGH PRQWSYERDE EMQERLDDDQ SEDMSAQDLN DMDQDDMCDD GSDIDDPSSE TDSKKGGSRN GDGKSGGGGG GGSKPRRART AFTYEQLVSL ENKFKTTRYL SVCERLNLAL SLSLTETQVK IWFQNRRTKW KKQNPGMDVN SPTIPPPGGG SFGPGAYASG LLYSHAVPYP PYGPYFHPLG AHHLSHSHS //