ID YCIC_ECOLI Reviewed; 247 AA. AC P21365; P77207; P94718; P94724; P94727; P94731; P94734; P94737; P97230; DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot. DT 11-JUL-2003, sequence version 2. DT 03-MAY-2023, entry version 135. DE RecName: Full=UPF0259 membrane protein YciC; GN Name=yciC; OrderedLocusNames=b1255, JW1247; OS Escherichia coli (strain K12). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=K12; RX PubMed=3058546; DOI=10.1093/genetics/120.2.345; RA Stoltzfus A., Leslie J.F., Milkman R.; RT "Molecular evolution of the Escherichia coli chromosome. I. Analysis of RT structure and natural variation in a previously uncharacterized region RT between trp and tonB."; RL Genetics 120:345-358(1988). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ECOR 1, ECOR 16, ECOR 28, ECOR 31, ECOR 37, ECOR 4, ECOR 46, RC ECOR 52, ECOR 60, ECOR 71, K12, and O2:HN / ECOR 50 / P97 / UPEC; RA Milkman R.; RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=9097039; DOI=10.1093/dnares/3.6.363; RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y., RA Wada C., Yamamoto Y., Horiuchi T.; RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to RT the 28.0-40.1 min region on the linkage map."; RL DNA Res. 3:363-377(1996). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., RA Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1462(1997). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 RT and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [6] RP TOPOLOGY [LARGE SCALE ANALYSIS]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=15919996; DOI=10.1126/science.1109730; RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.; RT "Global topology analysis of the Escherichia coli inner membrane RT proteome."; RL Science 308:1321-1323(2005). CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the UPF0259 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X13583; CAA31923.1; -; Genomic_DNA. DR EMBL; U24195; AAB60066.1; -; Genomic_DNA. DR EMBL; U24196; AAB60074.1; -; Genomic_DNA. DR EMBL; U24197; AAB60082.1; -; Genomic_DNA. DR EMBL; U24198; AAB60090.1; -; Genomic_DNA. DR EMBL; U24199; AAB60098.1; -; Genomic_DNA. DR EMBL; U24200; AAB60106.1; -; Genomic_DNA. DR EMBL; U24201; AAB60114.1; -; Genomic_DNA. DR EMBL; U24202; AAB60122.1; -; Genomic_DNA. DR EMBL; U24203; AAB60130.1; -; Genomic_DNA. DR EMBL; U24204; AAB60138.1; -; Genomic_DNA. DR EMBL; U24205; AAB60146.1; -; Genomic_DNA. DR EMBL; U24206; AAB60154.1; -; Genomic_DNA. DR EMBL; U00096; AAC74337.1; -; Genomic_DNA. DR EMBL; AP009048; BAA14787.1; -; Genomic_DNA. DR PIR; B64873; B64873. DR PIR; T45502; T45502. DR RefSeq; NP_415771.1; NC_000913.3. DR RefSeq; WP_000028545.1; NZ_LN832404.1. DR AlphaFoldDB; P21365; -. DR BioGRID; 4262999; 21. DR STRING; 511145.b1255; -. DR PaxDb; P21365; -. DR EnsemblBacteria; AAC74337; AAC74337; b1255. DR EnsemblBacteria; BAA14787; BAA14787; BAA14787. DR GeneID; 66674923; -. DR GeneID; 945844; -. DR KEGG; ecj:JW1247; -. DR KEGG; eco:b1255; -. DR PATRIC; fig|1411691.4.peg.1028; -. DR EchoBASE; EB1113; -. DR eggNOG; ENOG502Z96Y; Bacteria. DR HOGENOM; CLU_073287_0_0_6; -. DR OMA; FFRNQFV; -. DR OrthoDB; 6454524at2; -. DR PhylomeDB; P21365; -. DR BioCyc; EcoCyc:EG11123-MON; -. DR PRO; PR:P21365; -. DR Proteomes; UP000000318; Chromosome. DR Proteomes; UP000000625; Chromosome. DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc. DR HAMAP; MF_01067; UPF0259; 1. DR InterPro; IPR009627; UPF0259. DR Pfam; PF06790; UPF0259; 1. PE 1: Evidence at protein level; KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; KW Transmembrane; Transmembrane helix. FT CHAIN 1..247 FT /note="UPF0259 membrane protein YciC" FT /id="PRO_0000206514" FT TOPO_DOM 1..19 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 20..40 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 41..86 FT /note="Periplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 87..107 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 108..117 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 118..140 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 141..151 FT /note="Periplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 152..172 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 173..186 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 187..209 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 210..224 FT /note="Periplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 225..245 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 246..247 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT VARIANT 26 FT /note="V -> I (in strain: ECOR 52)" FT VARIANT 46 FT /note="A -> V (in strain: ECOR 31)" FT VARIANT 65 FT /note="D -> N (in strain: ECOR 16)" FT VARIANT 119 FT /note="I -> V (in strain: ECOR 60)" FT VARIANT 172 FT /note="V -> I (in strain: ECOR 16, ECOR 28, ECOR 31, ECOR FT 37, ECOR 50 and ECOR 71)" FT VARIANT 233 FT /note="I -> V (in strain: ECOR 31, ECOR 46, ECOR 50, ECOR FT 52 and ECOR 60)" FT CONFLICT 100..114 FT /note="VILIIQLVSAGQRVS -> RNINYPAGVCGSESQ (in Ref. 1 and FT 2)" FT /evidence="ECO:0000305" FT CONFLICT 191 FT /note="A -> T (in Ref. 1 and 2)" FT /evidence="ECO:0000305" FT CONFLICT 202 FT /note="T -> P (in Ref. 1 and 2)" FT /evidence="ECO:0000305" SQ SEQUENCE 247 AA; 26419 MW; C2750BF3A8ECF069 CRC64; MSITAQSVYR DTGNFFRNQF MTILLVSLLC AFITVVLGHV FSPSDAQLAQ LNDGVPVSGS SGLFDLVQNM SPEQQQILLQ ASAASTFSGL IGNAILAGGV ILIIQLVSAG QRVSALRAIG ASAPILPKLF ILIFLTTLLV QIGIMLVVVP GIIMAILLAL APVMLVQDKM GVFASMRSSM RLTWANMRLV APAVLSWLLA KTLLLLFASS FAALTPEIGA VLANTLSNLI SAILLIYLFR LYMLIRQ //