ID SUV3_DROME STANDARD; PRT; 1169 AA. AC P20193; Q9VFX7; DT 01-FEB-1991 (Rel. 17, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Suppressor of variegation protein 3-7. GN Name=Su(var)3-7; Synonyms=Suvar(3)7; ORFNames=CG8599; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95223788; PubMed=7708496; RA Cleard F., Matsarskaia M., Spierer P.; RT "The modifier of position-effect variegation Suvar(3)7 of Drosophila: RT there are two alternative transcripts and seven scattered zinc RT fingers, each preceded by a tryptophan box."; RL Nucleic Acids Res. 23:796-802(1995). RN [2] RP ERRATUM. RA Cleard F., Matsarskaia M., Spierer P.; RL Nucleic Acids Res. 23:3804-3804(1995). RN [3] RP SEQUENCE FROM N.A. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP SEQUENCE OF 255-1169 FROM N.A. RX MEDLINE=90190836; PubMed=2107402; RA Reuter G., Giarre M., Farah J., Gausz J., Spierer A., Spierer P.; RT "Dependence of position-effect variegation in Drosophila on dose of a RT gene encoding an unusual zinc-finger protein."; RL Nature 344:219-223(1990). RN [5] RP INTERACTION WITH SU(VAR)39. RX MEDLINE=21856321; PubMed=11867540; RA Schotta G., Ebert A., Krauss V., Fischer A., Hoffmann J., Rea S., RA Jenuwein T., Dorn R., Reuter G.; RT "Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation RT and heterochromatic gene silencing."; RL EMBO J. 21:1121-1131(2002). CC -!- FUNCTION: Dose-limiting factor in position-effect variegation, the CC inactivation in some cells of a gene translocated next to CC heterochromatin. It could play a role in chromosome condensation. CC -!- SUBUNIT: Interacts with Su(var)39. CC -!- SUBCELLULAR LOCATION: Nuclear (Probable). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X52187; CAA36434.1; -. DR EMBL; AE003699; AAF54918.1; -. DR PIR; S09151; S09151. DR IntAct; P20193; -. DR FlyBase; FBgn0003598; Su(var)3-7. DR InterPro; IPR004210; BESS_motif. DR InterPro; IPR007087; Znf_C2H2. DR Pfam; PF02944; BESS; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1. KW Zinc-finger; Nuclear protein; DNA-binding; Metal-binding; Repeat. FT ZN_FING 136 155 C2H2-type. FT ZN_FING 238 262 C2H2-type. FT ZN_FING 344 365 C2H2-type. FT ZN_FING 406 431 C2H2-type. FT ZN_FING 526 548 C2H2-type. FT ZN_FING 656 680 C2H2-type. FT ZN_FING 748 771 C2H2-type. FT DOMAIN 844 1057 Binds to Su(var)39. FT DOMAIN 86 92 Poly-Asp. FT DOMAIN 589 592 Poly-Glu. FT DOMAIN 780 788 Poly-Ala. FT DOMAIN 1008 1011 Poly-Asn. FT DOMAIN 1113 1116 Poly-Asn. FT CONFLICT 184 184 D -> S (in Ref. 1). FT CONFLICT 304 304 A -> V (in Ref. 3). FT CONFLICT 862 862 N -> D (in Ref. 3). FT CONFLICT 1067 1067 V -> L (in Ref. 3). FT CONFLICT 1078 1078 A -> V (in Ref. 3). FT CONFLICT 1112 1112 A -> V (in Ref. 3). SQ SEQUENCE 1169 AA; 131137 MW; 69C25C0E3EFA3357 CRC64; MRDDPCIEDI MDDEHAPLVA ELQSALNNPD DKQASEDPLL EDQEREPDAM STKTEPSSDA ESSHSYHDPM GLLERIEIHD PGDSQDDDDE DDESSNGGGV DGGMRRKMPR AQRWLLWMKR WPWILHEDSD GTLAFCLYCN ISINVNNRSR HIQQHNVSLS HQERECNYLA FKKSEEETRG AISDNEIKHE FGTKSYVAAM KQKRISETEA FNNFNWLRWL RWHPWLERSM PTGTIGTCRI CSVRMNVEFV YLRKRHETTK GHMEALRNLD SDKRSRKRKR SKSNSVTNSG GDEAEREKES EPEAGPEDAQ DTPVVMMNGD VDSGDDPGKW CALIPDTNPQ QCRCTLCNCT MAITSFLRHC KTRAHCHMLS TPAEKGSSDI RGIWAVFADM HPWLIADPED PSIGYCSVCR KRFMYGNSEI KRKNHEKSEK HTLALASAKA GIEVGSADGR GGDNMDEEEA AASDQAQSSQ TDDSEDNDDD NWSEIQKLGK GFAHKSSSEP RKATVRAGVR FYPWLCYSKD RKTQICKFCR VRFHNEAAKA RHELSARHVK LVKQFKMRQA KLHQGTNTQT KHNAQDDEES QEQDEEYGEE EEDAEEDSQS NFDLGTVQAR KTARADNKLF VKPIPATMKG KVMVWKGRFP WLSYKKNEQR GNYAWCKLCE VSLYLPSSKW ASKHQRTSRH IRLRIDRKRN GGNPLKTSNK NSGEISTVVA TASALASAEA RQKAAMAELQ AKYDWLDPDA NDENHCHCRV CDSRLPIKVF YLRQHDASRK HVENKERQRA NAAAAANAPS VSPTSTVDAE RQESGMDKES ENDMSVRSDG STAEPLAKRS RRSMEVRRII RALRDSMGKR QEERSQMDMA RNMICSSFDI VTRLRTLERE SVAHNESMAQ APPSVTVSPI KPPEPRHVMD LFFDSISPTM KSLPPDLAAE GKSKIMQLVC SLELRAMQRN ATTPTPATVS ASSKWPSSTT VTPVKTPPAP ISAPLASVDA DLHSSVVTTP HEYNNGQNNN NDKETVPKEP VTGASSAQVT INGSAKDLPE NIRRILTSNQ TQVTNRLETD SVRCVPVDKL TTQSRTNANG RLSQGGTSEA PSTPQADLSN GNTLAMIRQI RANNNNSSKI TVTNTPQMQQ PQQAQASITS STPIMRGGPS SNGCQITTFR TMVNHNRRP //