ID SUV3_DROME STANDARD; PRT; 1169 AA. AC P20193; DT 01-FEB-1991 (Rel. 17, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Suppressor of variegation protein 3-7. GN SUVAR(3)7. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95223788; PubMed=7708496; RA Cleard F., Matsarskaia M., Spierer P.; RT "The modifier of position-effect variegation Suvar(3)7 of Drosophila: RT there are two alternative transcripts and seven scattered zinc RT fingers, each preceded by a tryptophan box."; RL Nucleic Acids Res. 23:796-802(1995). RN [2] RP ERRATUM. RA Cleard F., Matsarskaia M., Spierer P.; RL Nucleic Acids Res. 23:3804-3804(1995). RN [3] RP SEQUENCE OF 255-1169 FROM N.A. RX MEDLINE=90190836; PubMed=2107402; RA Reuter G., Giarre M., Farah J., Gausz J., Spierer A., Spierer P.; RT "Dependence of position-effect variegation in Drosophila on dose of a RT gene encoding an unusual zinc-finger protein."; RL Nature 344:219-223(1990). CC -!- FUNCTION: THIS PROTEIN IS A DOSE-LIMITING FACTOR IN POSITION- CC EFFECT VARIEGATION, THE INACTIVATION IN SOME CELLS OF A GENE CC TRANSLOCATED NEXT TO HETEROCHROMATIN. IT COULD PLAY A ROLE IN CC CHROMOSOME CONDENSATION. CC -!- SUBCELLULAR LOCATION: NUCLEAR (PROBABLE). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X52187; CAA36434.1; -. DR PIR; S09151; S09151. DR FlyBase; FBgn0003598; Su(var)3-7. DR InterPro; IPR004210; BESS. DR InterPro; IPR000822; Znf-C2H2. DR Pfam; PF02944; BESS; 1. DR SMART; SM00355; ZnF_C2H2; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1. KW Zinc-finger; Nuclear protein; DNA-binding; Metal-binding; Repeat. FT ZN_FING 136 155 C2H2-TYPE. FT ZN_FING 238 262 C2H2-TYPE. FT ZN_FING 344 365 C2H2-TYPE. FT ZN_FING 406 431 C2H2-TYPE. FT ZN_FING 526 548 C2H2-TYPE. FT ZN_FING 656 680 C2H2-TYPE. FT ZN_FING 748 771 C2H2-TYPE. FT DOMAIN 86 92 POLY-ASP. FT DOMAIN 589 592 POLY-GLU. FT DOMAIN 780 788 POLY-ALA. FT DOMAIN 1008 1011 POLY-ASN. FT DOMAIN 1113 1116 POLY-ASN. SQ SEQUENCE 1169 AA; 131110 MW; A2B9380941645328 CRC64; MRDDPCIEDI MDDEHAPLVA ELQSALNNPD DKQASEDPLL EDQEREPDAM STKTEPSSDA ESSHSYHDPM GLLERIEIHD PGDSQDDDDE DDESSNGGGV DGGMRRKMPR AQRWLLWMKR WPWILHEDSD GTLAFCLYCN ISINVNNRSR HIQQHNVSLS HQERECNYLA FKKSEEETRG AISSNEIKHE FGTKSYVAAM KQKRISETEA FNNFNWLRWL RWHPWLERSM PTGTIGTCRI CSVRMNVEFV YLRKRHETTK GHMEALRNLD SDKRSRKRKR SKSNSVTNSG GDEAEREKES EPEAGPEDAQ DTPVVMMNGD VDSGDDPGKW CALIPDTNPQ QCRCTLCNCT MAITSFLRHC KTRAHCHMLS TPAEKGSSDI RGIWAVFADM HPWLIADPED PSIGYCSVCR KRFMYGNSEI KRKNHEKSEK HTLALASAKA GIEVGSADGR GGDNMDEEEA AASDQAQSSQ TDDSEDNDDD NWSEIQKLGK GFAHKSSSEP RKATVRAGVR FYPWLCYSKD RKTQICKFCR VRFHNEAAKA RHELSARHVK LVKQFKMRQA KLHQGTNTQT KHNAQDDEES QEQDEEYGEE EEDAEEDSQS NFDLGTVQAR KTARADNKLF VKPIPATMKG KVMVWKGRFP WLSYKKNEQR GNYAWCKLCE VSLYLPSSKW ASKHQRTSRH IRLRIDRKRN GGNPLKTSNK NSGEISTVVA TASALASAEA RQKAAMAELQ AKYDWLDPDA NDENHCHCRV CDSRLPIKVF YLRQHDASRK HVENKERQRA NAAAAANAPS VSPTSTVDAE RQESGMDKES ENDMSVRSDG STAEPLAKRS RRSMEVRRII RALRDSMGKR QEERSQMDMA RNMICSSFDI VTRLRTLERE SVAHNESMAQ APPSVTVSPI KPPEPRHVMD LFFDSISPTM KSLPPDLAAE GKSKIMQLVC SLELRAMQRN ATTPTPATVS ASSKWPSSTT VTPVKTPPAP ISAPLASVDA DLHSSVVTTP HEYNNGQNNN NDKETVPKEP VTGASSAQVT INGSAKDLPE NIRRILTSNQ TQVTNRLETD SVRCVPVDKL TTQSRTNANG RLSQGGTSEA PSTPQADLSN GNTLAMIRQI RANNNNSSKI TVTNTPQMQQ PQQAQASITS STPIMRGGPS SNGCQITTFR TMVNHNRRP //