ID MLC1_ONCKE STANDARD; PRT; 132 AA. AC P19713; P01208; DT 01-FEB-1991 (REL. 17, CREATED) DT 01-FEB-1991 (REL. 17, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE MELANIN-CONCENTRATING HORMONE 1 PRECURSOR. GN MCH1. OS ONCORHYNCHUS KETA (CHUM SALMON). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; ACTINOPTERYGII; NEOPTERYGII; OC TELEOSTEI; EUTELEOSTEI; PROTACANTHOPTERYGII; SALMONIFORMES; OC SALMONIDAE; ONCORHYNCHUS. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 90006787. RA TAKAYAMA Y., WADA C., KAWAUCHI H., ONO M.; RT "Structures of two genes coding for melanin-concentrating hormone of RT chum salmon."; RL GENE 80:65-73(1989). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 89138019. RA ONO M., WADA C., OIKAWA I., KAWAZOE I., KAWAUCHI H.; RT "Structures of two kinds of mRNA encoding the chum salmon melanin- RT concentrating hormone."; RL GENE 71:433-438(1988). RN [3] RP SEQUENCE OF 116-132. RX MEDLINE; 84014069. RA KAWAUCHI H., KAWAZOE I., TSUBOKAWA M., KISHIDA M., BAKER B.I.; RT "Characterization of melanin-concentrating hormone in chum salmon RT pituitaries."; RL NATURE 305:321-323(1983). CC -!- FUNCTION: THIS HORMONE, ISOLATED FROM THE PITUITARY GLAND, HAS AN CC ACTIVITY ANTAGONISTIC TO MELANOTROPIN. CC -!- SIMILARITY: TO OTHER SPECIES MCH AND TO APLYSIA ATRIAL GLAND CC PEPTIDE A. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M27872; G213453; -. DR EMBL; M23573; G213457; -. DR PIR; JS0282; MTON1K. KW SIGNAL; CLEAVAGE ON PAIR OF BASIC RESIDUES; HORMONE; PITUITARY; KW NEUROPEPTIDE; MULTIGENE FAMILY. FT SIGNAL 1 24 FT PEPTIDE 116 132 MELANIN-CONCENTRATING HORMONE. FT DISULFID 120 129 FT CONFLICT 4 4 Y -> S (IN REF. 2). SQ SEQUENCE 132 AA; 14682 MW; 182E19CA CRC32; MRHYVLSISF AVALFLECYT PSTAISIGKM DDVALEQDTL DSLLSVEVSE NSPDSVRGRS SKIVLLADSG LWMNLNRGLP FYKLRAAAAG PDRALTLDRR EAGQDLSPSI SIVRRDTMRC MVGRVYRPCW EV //