ID MLC1_ONCKE STANDARD; PRT; 132 AA. AC P19713; P01208; DT 01-FEB-1991 (REL. 17, CREATED) DT 01-FEB-1991 (REL. 17, LAST SEQUENCE UPDATE) DT 01-FEB-1991 (REL. 17, LAST ANNOTATION UPDATE) DE MELANIN-CONCENTRATING HORMONE 1 PRECURSOR. GN MCH1. OS ONCORHYNCHUS KETA (CHUM SALMON). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; PISCES; GNATHOSTOMATA; OC OSTEICHTHYES; ACTINOPTERYGII; SALMONIFORMES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 90006787. RA TAKAYAMA Y., WADA C., KAWAUCHI H., ONO M.; RL GENE 80:65-73(1989). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 89138019. RA ONO M., WADA C., OIKAWA I., KAWAZOE I., KAWAUCHI H.; RL GENE 71:433-438(1988). RN [3] RP SEQUENCE OF 116-132. RX MEDLINE; 84014069. RA KAWAUCHI H., KAWAZOE I., TSUBOKAWA M., KISHIDA M., BAKER B.I.; RL NATURE 305:321-323(1983). CC -!- FUNCTION: THIS HORMONE, ISOLATED FROM THE PITUITARY GLAND, HAS AN CC ACTIVITY ANTAGONISTIC TO MELANOTROPIN. CC -!- SIMILARITY: 28% IDENTITY TO RAT MCH-PRECURSOR AND TO APLYSIA CC ATRIAL GLAND PEPTIDE A PRECURSOR. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M27872; M27872. DR EMBL; M23573; M23573. DR PIR; JS0282; MTON1K. KW SIGNAL; CLEAVAGE ON PAIR OF BASIC RESIDUES; HORMONE; PITUITARY; KW NEUROPEPTIDE; MULTIGENE FAMILY. FT SIGNAL 1 24 FT PEPTIDE 116 132 MELANIN-CONCENTRATING HORMONE. FT DISULFID 120 129 FT CONFLICT 4 4 Y -> S (IN REF. 2). SQ SEQUENCE 132 AA; 14682 MW; 85958 CN; MRHYVLSISF AVALFLECYT PSTAISIGKM DDVALEQDTL DSLLSVEVSE NSPDSVRGRS SKIVLLADSG LWMNLNRGLP FYKLRAAAAG PDRALTLDRR EAGQDLSPSI SIVRRDTMRC MVGRVYRPCW EV //