ID MLC1_ONCKE STANDARD; PRT; 132 AA. AC P19713; P01208; DT 01-FEB-1991 (Rel. 17, Created) DT 01-FEB-1991 (Rel. 17, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Pro-MCH 1 precursor [Contains: Neuropeptide-glutamic acid-valine (NEV) DE (Neuropeptide E-V); Melanin-concentrating hormone (MCH)]. GN MCH1. OS Oncorhynchus keta (Chum salmon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; OC Protacanthopterygii; Salmoniformes; Salmonidae; Oncorhynchus. OX NCBI_TaxID=8018; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=90006787; PubMed=2792771; RA Takayama Y., Wada C., Kawauchi H., Ono M.; RT "Structures of two genes coding for melanin-concentrating hormone of RT chum salmon."; RL Gene 80:65-73(1989). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=89138019; PubMed=2465207; RA Ono M., Wada C., Oikawa I., Kawazoe I., Kawauchi H.; RT "Structures of two kinds of mRNA encoding the chum salmon melanin- RT concentrating hormone."; RL Gene 71:433-438(1988). RN [3] RP SEQUENCE OF 116-132. RX MEDLINE=84014069; PubMed=6621686; RA Kawauchi H., Kawazoe I., Tsubokawa M., Kishida M., Baker B.I.; RT "Characterization of melanin-concentrating hormone in chum salmon RT pituitaries."; RL Nature 305:321-323(1983). CC -!- FUNCTION: PLAYS A ROLE IN SKIN PIGMENTATION BY ANTAGONIZING THE CC ACTION OF MELANOTROPIN ALPHA. INDUCES MELANIN CONCENTRATION WITHIN CC THE MELANOPHORES. MAY PARTICIPATE IN THE CONTROL OF THE CC HYPOTHALAMO-PITUITARY ADRENAL GLAND AXIS BY INHIBITING THE RELEASE CC OF ACTH. CC -!- TISSUE SPECIFICITY: PITUITARY GLAND. PRODUCED IN NEURONS OF CC LATERAL BASAL HYPOTHALAMUS WHICH PROJECT BOTH TO THE BRAIN AND TO CC THE NEURAL LOBE OF THE PITUITARY GLAND FROM WHERE MCH IS RELEASED. CC -!- SIMILARITY: BELONGS TO THE MELANIN-CONCENTRATING HORMONE FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M27872; AAA49418.1; -. DR EMBL; M23573; AAA49420.1; -. DR PIR; JS0282; MTON1K. KW Cleavage on pair of basic residues; Hormone; Neuropeptide; Signal; KW Multigene family. FT SIGNAL 1 24 FT CHAIN 25 132 PRO-MCH 1. FT PEPTIDE 101 113 NEV (POTENTIAL). FT PEPTIDE 116 132 MELANIN-CONCENTRATING HORMONE. FT DISULFID 120 129 FT CONFLICT 4 4 Y -> S (IN REF. 2). SQ SEQUENCE 132 AA; 14682 MW; CE9CF95292498738 CRC64; MRHYVLSISF AVALFLECYT PSTAISIGKM DDVALEQDTL DSLLSVEVSE NSPDSVRGRS SKIVLLADSG LWMNLNRGLP FYKLRAAAAG PDRALTLDRR EAGQDLSPSI SIVRRDTMRC MVGRVYRPCW EV //