ID HME2_HUMAN Reviewed; 333 AA. AC P19622; DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot. DT 11-JUL-2002, sequence version 3. DT 23-JAN-2007, entry version 59. DE Homeobox protein engrailed-2 (Hu-En-2). GN Name=EN2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=93185339; PubMed=1363401; RA Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., RA Joyner A.L.; RT "Cloning and sequence comparison of the mouse, human, and chicken RT engrailed genes reveal potential functional domains and regulatory RT regions."; RL Dev. Genet. 13:345-358(1992). RN [2] RP SEQUENCE REVISION TO 229. RA Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., RA Joyner A.L.; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 230-333. RX MEDLINE=89233109; PubMed=2565873; RA Poole S.J., Law M.L., Kao F.T., Lau Y.-F.C.; RT "Isolation and chromosomal localization of the human En-2 gene."; RL Genomics 4:225-231(1989). CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- SIMILARITY: Belongs to the engrailed homeobox family. CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L12701; AAA53504.2; -; Genomic_DNA. DR EMBL; L12700; AAA53504.2; JOINED; Genomic_DNA. DR EMBL; J03066; AAF68670.1; -; Genomic_DNA. DR PIR; E48423; E48423. DR UniGene; Hs.134989; -. DR HSSP; P02836; 3HDD. DR SMR; P19622; 246-301. DR TRANSFAC; T02019; -. DR Ensembl; ENSG00000164778; Homo sapiens. DR KEGG; hsa:2020; -. DR HGNC; HGNC:3343; EN2. DR MIM; 131310; gene. DR ArrayExpress; P19622; -. DR GermOnline; ENSG00000164778; Homo sapiens. DR GO; GO:0007275; P:development; TAS:ProtInc. DR InterPro; IPR000747; Engrailed. DR InterPro; IPR001356; Homeobox. DR InterPro; IPR012287; Homeodomain-rel. DR InterPro; IPR009057; Homeodomain_like. DR InterPro; IPR000047; HTH_lambrepressr. DR Gene3D; G3DSA:1.10.10.60; Homeodomain-rel; 1. DR Pfam; PF00046; Homeobox; 1. DR PRINTS; PR00026; ENGRAILED. DR PRINTS; PR00024; HOMEOBOX. DR PRINTS; PR00031; HTHREPRESSR. DR ProDom; PD000010; Homeobox; 1. DR SMART; SM00389; HOX; 1. DR PROSITE; PS00033; ENGRAILED; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. KW Developmental protein; DNA-binding; Homeobox; Nuclear protein; KW Polymorphism. FT CHAIN 1 333 Homeobox protein engrailed-2. FT /FTId=PRO_0000196067. FT DNA_BIND 244 303 Homeobox. FT VARIANT 121 121 L -> F (in dbSNP:rs3735653). FT /FTId=VAR_021985. SQ SEQUENCE 333 AA; 34211 MW; ACF5399E383D6257 CRC64; MEENDPKPGE AAAAVEGQRQ PESSPGGGSG GGGGSSPGEA DTGRRRALML PAVLQAPGNH QHPHRITNFF IDNILRPEFG RRKDAGTCCA GAGGGRGGGA GGEGGASGAE GGGGAGGSEQ LLGSGSREPR QNPPCAPGAG GPLPAAGSDS PGDGEGGSKT LSLHGGAKKG GDPGGPLDGS LKARGLGGGD LSVSSDSDSS QAGANLGAQP MLWPAWVYCT RYSDRPSSGP RSRKPKKKNP NKEDKRPRTA FTAEQLQRLK AEFQTNRYLT EQRRQSLAQE LSLNESQIKI WFQNKRAKIK KATGNKNTLA VHLMAQGLYN HSTTAKEGKS DSE //