ID HME2_HUMAN STANDARD; PRT; 332 AA. AC P19622; DT 01-FEB-1991 (Rel. 17, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Homeobox protein engrailed-2 (Hu-En-2). GN EN2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93185339; PubMed=1363401; RA Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., RA Provart N.J., Joyner A.L.; RT "Cloning and sequence comparison of the mouse, human, and chicken RT engrailed genes reveal potential functional domains and regulatory RT regions."; RL Dev. Genet. 13:345-358(1992). RN [2] RP SEQUENCE OF 229-332 FROM N.A. RX MEDLINE=89233109; PubMed=2565873; RA Poole S.J., Law M.L., Kao F.T., Lau Y.F.; RT "Isolation and chromosomal localization of the human En-2 gene."; RL Genomics 4:225-231(1989). CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- SIMILARITY: BELONGS TO THE ENGRAILED FAMILY OF HOMEOBOX PROTEINS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L12700; AAA53503.1; -. DR EMBL; L12701; AAA53504.1; -. DR PIR; A30141; A30141. DR HSSP; P02836; 3HDD. DR TRANSFAC; T02019; -. DR MIM; 131310; -. DR InterPro; IPR000747; Engrailed. DR InterPro; IPR001356; Homeobox. DR Pfam; PF00046; homeobox; 1. DR PRINTS; PR00026; ENGRAILED. DR PRINTS; PR00024; HOMEOBOX. DR SMART; SM00389; HOX; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00033; ENGRAILED; 1. KW Homeobox; DNA-binding; Developmental protein; Nuclear protein. FT DNA_BIND 243 302 HOMEOBOX. SQ SEQUENCE 332 AA; 34153 MW; 3B3FCA4F5E1B502E CRC64; MEENDPKPGE AAAAVEGQRQ PESSPGGGSG GGGGSSPGEA DTGRRRALML PAVLQAPGNH QHPHRITNFF IDNILRPEFG RRKDAGTCCA GAGGGRGGGA GGEGGASGAE GGGGAGGSEQ LLGSGSREPR QNPPCAPGAG GPLPAAGSDS PGDGEGGSKT LSLHGGAKKG GDPGGPLDGS LKARGLGGGD LSVSSDSDSS QAGANLGAQP MLWPAWVYCT RYSDRPSSPR SRKPKKKNPN KEDKRPRTAF TAEQLQRLKA EFQTNRYLTE QRRQSLAQEL SLNESQIKIW FQNKRAKIKK ATGNKNTLAV HLMAQGLYNH STTAKEGKSD SE //