ID ADT3_YEAST Reviewed; 307 AA. AC P18238; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 1. DT 22-JUL-2008, entry version 73. DE RecName: Full=ADP,ATP carrier protein 3; DE AltName: Full=ADP/ATP translocase 3; DE AltName: Full=Adenine nucleotide translocator 3; DE Short=ANT 3; GN Name=AAC3; OrderedLocusNames=YBR085W; ORFNames=YBR0753; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; OC Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=90324269; PubMed=2165073; RA Kolarov J., Kolarova N., Nelson N.; RT "A third ADP/ATP translocator gene in yeast."; RL J. Biol. Chem. 265:12711-12716(1990). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX MEDLINE=95112788; PubMed=7813418; RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H., RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., RA Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., RA Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., RA Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., RA Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., RA Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., RA Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., RA Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., RA Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., RA Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., RA Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., RA van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., RA Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., RA Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.; RT "Complete DNA sequence of yeast chromosome II."; RL EMBO J. 13:5795-5809(1994). RN [3] RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. RX MEDLINE=22923965; PubMed=14562106; DOI=10.1038/nature02046; RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., RA Dephoure N., O'Shea E.K., Weissman J.S.; RT "Global analysis of protein expression in yeast."; RL Nature 425:737-741(2003). CC -!- FUNCTION: Catalyzes the exchange of ADP and ATP across the CC mitochondrial inner membrane. CC -!- SUBUNIT: Homodimer. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein. CC -!- MISCELLANEOUS: The transmembrane helices are not perpendicular to CC the plane of the membrane, but cross the membrane at an angle. At CC least 2 of the odd-numbered transmembrane helices exhibit a sharp CC kink, due to the presence of a conserved proline residue (By CC similarity). CC -!- MISCELLANEOUS: Present with 1080 molecules/cell in log phase SD CC medium. CC -!- SIMILARITY: Belongs to the mitochondrial carrier family. CC -!- SIMILARITY: Contains 3 Solcar repeats. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M34076; AAA97485.1; -; Genomic_DNA. DR EMBL; Z35954; CAA85031.1; -; Genomic_DNA. DR PIR; A36582; A36582. DR RefSeq; NP_009642.1; -. DR DIP; DIP:6289N; -. DR IntAct; P18238; -. DR PeptideAtlas; P18238; -. DR Ensembl; YBR085W; Saccharomyces cerevisiae. DR GeneID; 852380; -. DR GenomeReviews; Y13134_GR; YBR085W. DR KEGG; sce:YBR085W; -. DR NMPDR; fig|4932.3.peg.340; -. DR CYGD; YBR085w; -. DR SGD; S000000289; AAC3. DR HOGENOM; P18238; -. DR LinkHub; P18238; -. DR ArrayExpress; P18238; -. DR GermOnline; YBR085W; Saccharomyces cerevisiae. DR GO; GO:0005739; C:mitochondrion; IDA:SGD. DR GO; GO:0009061; P:anaerobic respiration; IGI:SGD. DR InterPro; IPR002113; Aden_trnslctor. DR InterPro; IPR002067; Mit_carrier. DR InterPro; IPR001993; Mitoch_carrier. DR PANTHER; PTHR11896; Mitoch_carrier; 1. DR Pfam; PF00153; Mito_carr; 3. DR PRINTS; PR00927; ADPTRNSLCASE. DR PRINTS; PR00926; MITOCARRIER. DR PROSITE; PS50920; SOLCAR; 3. PE 1: Evidence at protein level; KW Complete proteome; Membrane; Mitochondrion; KW Mitochondrion inner membrane; Repeat; Transmembrane; Transport. FT CHAIN 1 307 ADP,ATP carrier protein 3. FT /FTId=PRO_0000090595. FT TRANSMEM 9 43 1 (By similarity). FT TRANSMEM 80 104 2 (By similarity). FT TRANSMEM 112 146 3 (By similarity). FT TRANSMEM 181 208 4 (By similarity). FT TRANSMEM 213 247 5 (By similarity). FT TRANSMEM 276 301 6 (By similarity). FT REPEAT 10 103 Solcar 1. FT REPEAT 114 206 Solcar 2. FT REPEAT 214 300 Solcar 3. FT MOTIF 241 246 Substrate recognition (By similarity). FT BINDING 85 85 Nucleotide (By similarity). SQ SEQUENCE 307 AA; 33313 MW; D0C1329FEC1B4DC8 CRC64; MSSDAKQQET NFAINFLMGG VSAAIAKTAA SPIERVKILI QNQDEMIKQG TLDKKYSGIV DCFKRTAKQE GLISFWRGNT ANVIRYFPTQ ALNFAFKDKI KLMFGFKKEE GYGKWFAGNL ASGGAAGALS LLFVYSLDFA RTRLAADAKS SKKGGARQFN GLTDVYKKTL KSDGIAGLYR GFMPSVVGIV VYRGLYFGMF DSLKPLVLTG SLDGSFLASF LLGWVVTTGA STCSYPLDTV RRRMMMTSGQ AVKYNGAIDC LKKIVASEGV GSLFKGCGAN ILRSVAGAGV ISMYDQLQMI LFGKKFK //