ID   MTB2_BACAM              Reviewed;         265 AA.
AC   P18051;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   13-NOV-2019, entry version 88.
DE   RecName: Full=Modification methylase BamHII;
DE            Short=M.BamHII;
DE            EC=2.1.1.113;
DE   AltName: Full=N(4)-cytosine-specific methyltransferase BamHII;
GN   Name=bamHIIM;
OS   Bacillus amyloliquefaciens (Bacillus velezensis).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus amyloliquefaciens group.
OX   NCBI_TaxID=1390;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H;
RX   PubMed=2374727; DOI=10.1093/nar/18.13.4002;
RA   Connaughton J.F., Kaloss W.D., Vanek P.G., Nardone G.A.,
RA   Chirikjian J.G.;
RT   "The complete sequence of the Bacillus amyloliquefaciens proviral H2,
RT   BamHI methylase gene.";
RL   Nucleic Acids Res. 18:4002-4002(1990).
CC   -!- FUNCTION: This methylase recognizes the double-stranded sequence
CC       GGATCC, causes specific methylation on C-5 on both strands, and
CC       protects the DNA from cleavage by the BamHI endonuclease.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an
CC         N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369,
CC         Rhea:RHEA-COMP:13674, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:85452, ChEBI:CHEBI:137933;
CC         EC=2.1.1.113;
CC   -!- MISCELLANEOUS: This methylase is encoded on the proviral phage H2.
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC       N(4) subfamily. {ECO:0000305}.
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DR   EMBL; X53032; CAA37205.1; -; Genomic_DNA.
DR   PIR; S10316; S10316.
DR   REBASE; 157607; M2.Rso10709ORF7P.
DR   REBASE; 204726; M.Bso1395ORF2761P.
DR   BRENDA; 2.1.1.113; 630.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   InterPro; IPR002941; DNA_methylase_N4/N6.
DR   InterPro; IPR017985; MeTrfase_CN4_CS.
DR   InterPro; IPR001091; RM_Methylase.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF01555; N6_N4_Mtase; 1.
DR   PRINTS; PR00508; S21N4MTFRASE.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS00093; N4_MTASE; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Restriction system; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN         1    265       Modification methylase BamHII.
FT                                /FTId=PRO_0000087921.
SQ   SEQUENCE   265 AA;  30981 MW;  895A51217A814820 CRC64;
     MKENIGDCTI DLTVTSPPYD DLRNYNGYSF NFEETAQELY RVTKEGGVVV WVVGDKTHKG
     SETGSSFRQA LYFKELGFNL HDTMIYEKDS ISFPDKNRYY QIFEYMFIFS KGKPKTINLL
     ADRKNKWYNG KKHIKGHYRK MDGEKVRHHK QNLLKEFGVR FNIWRIPNGH QKSTLDKIAF
     QHPAIFPEKL AEDHILSWSN EGDIVFDPFM GSGTTAKMAA LNNRKYIGTE ISKEYCDIAN
     ERLKNYIILH KRMEGKGYRL PQVHS
//