ID MTB2_BACAM Reviewed; 265 AA. AC P18051; DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 1. DT 09-JAN-2013, entry version 72. DE RecName: Full=Modification methylase BamHII; DE Short=M.BamHII; DE EC=2.1.1.113; DE AltName: Full=N(4)-cytosine-specific methyltransferase BamHII; GN Name=bamHIIM; OS Bacillus amyloliquefaciens (Bacillus velezensis). OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. OX NCBI_TaxID=1390; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=H; RX MEDLINE=90326538; PubMed=2374727; DOI=10.1093/nar/18.13.4002; RA Connaughton J.F., Kaloss W.D., Vanek P.G., Nardone G.A., RA Chirikjian J.G.; RT "The complete sequence of the Bacillus amyloliquefaciens proviral H2, RT BamHI methylase gene."; RL Nucleic Acids Res. 18:4002-4002(1990). CC -!- FUNCTION: This methylase recognizes the double-stranded sequence CC GGATCC, causes specific methylation on C-5 on both strands, and CC protects the DNA from cleavage by the BamHI endonuclease. CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + DNA cytosine = S- CC adenosyl-L-homocysteine + DNA N(4)-methylcytosine. CC -!- MISCELLANEOUS: This methylase is encoded on the proviral phage H2. CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. CC N(4) subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X53032; CAA37205.1; -; Genomic_DNA. DR PIR; S10316; S10316. DR ProteinModelPortal; P18051; -. DR REBASE; 186; M.BamHII. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro. DR GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:EC. DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW. DR InterPro; IPR002941; DNA_methylase_N4/N6. DR InterPro; IPR017985; MeTrfase_CN4_CS. DR InterPro; IPR001091; RM_Methylase. DR Pfam; PF01555; N6_N4_Mtase; 1. DR PRINTS; PR00508; S21N4MTFRASE. DR PROSITE; PS00093; N4_MTASE; 1. PE 3: Inferred from homology; KW Methyltransferase; Restriction system; S-adenosyl-L-methionine; KW Transferase. FT CHAIN 1 265 Modification methylase BamHII. FT /FTId=PRO_0000087921. SQ SEQUENCE 265 AA; 30981 MW; 895A51217A814820 CRC64; MKENIGDCTI DLTVTSPPYD DLRNYNGYSF NFEETAQELY RVTKEGGVVV WVVGDKTHKG SETGSSFRQA LYFKELGFNL HDTMIYEKDS ISFPDKNRYY QIFEYMFIFS KGKPKTINLL ADRKNKWYNG KKHIKGHYRK MDGEKVRHHK QNLLKEFGVR FNIWRIPNGH QKSTLDKIAF QHPAIFPEKL AEDHILSWSN EGDIVFDPFM GSGTTAKMAA LNNRKYIGTE ISKEYCDIAN ERLKNYIILH KRMEGKGYRL PQVHS //