ID HGF_RAT STANDARD; PRT; 728 AA. AC P17945; DT 01-NOV-1990 (REL. 16, CREATED) DT 01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE) DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE) DE HEPATOCYTE GROWTH FACTOR PRECURSOR (HGF). OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. RC STRAIN=WISTAR; TISSUE=LIVER; RM 90222197 RA TOSHIRO K., HAGIYA M., NISHIZAWA T., SEKI T., SHIMONISHI M., RA SHIMIZU S., NAKAMURA T.; RL PROC. NATL. ACAD. SCI. U.S.A. 87:3200-3204(1990). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=WISTAR; TISSUE=LIVER; RM 91031482 RA OKAJIMA A., MIYAZAWA K., KITAMURA N.; RL EUR. J. BIOCHEM. 193:375-381(1990). CC -!- FUNCTION: HGF IS A POTENT MITOGEN FOR MATURE PARENCHYMAL CC HEPATOCYTE CELLS, SEEMS TO BE AN HEPATOTROPHIC FACTOR, AND ACTS CC AS GROWTH FACTOR FOR A BROAD SPECTRUM OF TISSUES AND CELL TYPES. CC IT HAS NO DETECTABLE PROTEASE ACTIVITY. CC -!- SUBUNIT: DIMER OF AN ALPHA CHAIN AND A BETA CHAIN LINKED BY A CC DISULFIDE BOND. CC -!- SIMILARITY: CONTAINS FOUR KRINGLE REGIONS. CC -!- SIMILARITY: HIGH, TO OTHER HGF; LOWER, TO PLASMINOGEN. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D90102; RNHGF01. DR EMBL; M32987; RNHGF. DR EMBL; X54400; RNHGFR. DR PIR; S13211; S13211. DR PIR; A35644; A35644. DR PROSITE; PS00021; KRINGLE. KW GROWTH FACTOR; KRINGLE; GLYCOPROTEIN; SERINE PROTEASE HOMOLOG; KW SIGNAL. FT SIGNAL 1 32 BY SIMILARITY. FT CHAIN 33 495 HGF, ALPHA CHAIN. FT CHAIN 496 728 HGF, BETA CHAIN. FT MOD_RES 33 33 PYRROLIDONE CARBOXYLIC ACID FT (BY SIMILARITY). FT DOMAIN 129 207 KRINGLE 1. FT DOMAIN 212 289 KRINGLE 2. FT DOMAIN 306 384 KRINGLE 3. FT DOMAIN 392 470 KRINGLE 4. FT DOMAIN 496 728 SERINE PROTEASE-LIKE. FT DISULFID 488 607 INTERCHAIN (BY SIMILARITY). FT CARBOHYD 295 295 POTENTIAL. FT CARBOHYD 403 403 POTENTIAL. FT CARBOHYD 569 569 POTENTIAL. FT CARBOHYD 656 656 POTENTIAL. SQ SEQUENCE 728 AA; 82905 MW; 2744241 CN; MMWGTKLLPV LLLQHVLLHL LLLPVTIPYA EGQKKRRNTL HEFKKSAKTT LTKEDPLVKI KTKKVNSADE CANRCIRNKG FPFTCKAFVF DKSRKRCYWY PFNSMSSGVK KGFGHEFDLY ENKDYIRNCI IGKGGSYKGT VSITKSGIKC QPWNSMIPHE HSFLPSSYRG KDLQENYCRN PRGEEGGPWC FTSNPEVRYE VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT PHRHKFLPER YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKMCA HSAVNETDVP METTECIKGQ GEGYRGTTNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL RENYCRNPDG AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY MGNLSKTRSG LTCSMWDKNM EDLHRHIFWE PDASKLTKNY CRNPDDDAHG PWCYTGNPLV PWDYCPISRC EGDTTPTIVN LDHPVISCAK TKQLRVVNGI PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR NKDLKDYEAW LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ GKVTLNESEL CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC AIPNRPGIFV RVAYYAKWIH KVILTYKL //