ID HGF_RAT STANDARD; PRT; 728 AA. AC P17945; DT 01-NOV-1990 (Rel. 16, Created) DT 01-NOV-1990 (Rel. 16, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE Hepatocyte growth factor precursor (Scatter factor) (SF) DE (Hepatopoeitin A). GN HGF. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. RC STRAIN=WISTAR; TISSUE=Liver; RX MEDLINE=90222197; PubMed=2139229; RA Toshiro K., Hagiya M., Nishizawa T., Seki T., Shimonishi M., RA Shimizu S., Nakamura T.; RT "Deduced primary structure of rat hepatocyte growth factor and RT expression of the mRNA in rat tissues."; RL Proc. Natl. Acad. Sci. U.S.A. 87:3200-3204(1990). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=WISTAR; TISSUE=Liver; RX MEDLINE=91031482; PubMed=2146117; RA Okajima A., Miyazawa K., Kitamura N.; RT "Primary structure of rat hepatocyte growth factor and induction of RT its mRNA during liver regeneration following hepatic injury."; RL Eur. J. Biochem. 193:375-381(1990). CC -!- FUNCTION: HGF IS A POTENT MITOGEN FOR MATURE PARENCHYMAL CC HEPATOCYTE CELLS, SEEMS TO BE AN HEPATOTROPHIC FACTOR, AND ACTS CC AS GROWTH FACTOR FOR A BROAD SPECTRUM OF TISSUES AND CELL TYPES. CC IT HAS NO DETECTABLE PROTEASE ACTIVITY. CC -!- SUBUNIT: DIMER OF AN ALPHA CHAIN AND A BETA CHAIN LINKED BY A CC DISULFIDE BOND. CC -!- SIMILARITY: CONTAINS 4 KRINGLE DOMAINS. CC -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY S1; ALSO KNOWN AS THE CC TRYPSIN FAMILY. PLASMINOGEN SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D90102; BAA14133.1; -. DR EMBL; X54400; CAA38266.1; -. DR PIR; S13211; S13211. DR PIR; A35644; A35644. DR HSSP; P14210; 2HGF. DR MEROPS; S01.978; -. DR InterPro; IPR001314; Chymotrypsin. DR InterPro; IPR000001; Kringle. DR InterPro; IPR003014; PAN. DR InterPro; IPR003609; Pan_app. DR InterPro; IPR001254; Trypsin. DR Pfam; PF00051; kringle; 4. DR Pfam; PF00024; PAN; 1. DR Pfam; PF00089; trypsin; 1. DR PRINTS; PR00018; KRINGLE. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00130; KR; 4. DR SMART; SM00473; PAN_AP; 1. DR SMART; SM00020; Tryp_SPc; 1. DR PROSITE; PS00021; KRINGLE_1; 4. DR PROSITE; PS50070; KRINGLE_2; 4. DR PROSITE; PS50240; TRYPSIN_DOM; 1. KW Growth factor; Kringle; Glycoprotein; Serine protease homolog; KW Signal. FT SIGNAL 1 32 BY SIMILARITY. FT CHAIN 33 495 HEPATOCYTE GROWTH FACTOR ALPHA CHAIN. FT CHAIN 496 728 HEPATOCYTE GROWTH FACTOR BETA CHAIN. FT MOD_RES 33 33 PYRROLIDONE CARBOXYLIC ACID FT (BY SIMILARITY). FT DOMAIN 33 128 PAP. FT DOMAIN 129 207 KRINGLE 1. FT DOMAIN 212 289 KRINGLE 2. FT DOMAIN 306 384 KRINGLE 3. FT DOMAIN 392 470 KRINGLE 4. FT DOMAIN 496 728 SERINE PROTEASE-LIKE. FT DISULFID 71 97 BY SIMILARITY. FT DISULFID 75 85 BY SIMILARITY. FT DISULFID 488 607 INTERCHAIN (BY SIMILARITY). FT CARBOHYD 295 295 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 403 403 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 569 569 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 656 656 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 728 AA; 82905 MW; 3E0BF1F96ADCEDFF CRC64; MMWGTKLLPV LLLQHVLLHL LLLPVTIPYA EGQKKRRNTL HEFKKSAKTT LTKEDPLVKI KTKKVNSADE CANRCIRNKG FPFTCKAFVF DKSRKRCYWY PFNSMSSGVK KGFGHEFDLY ENKDYIRNCI IGKGGSYKGT VSITKSGIKC QPWNSMIPHE HSFLPSSYRG KDLQENYCRN PRGEEGGPWC FTSNPEVRYE VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT PHRHKFLPER YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKMCA HSAVNETDVP METTECIKGQ GEGYRGTTNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL RENYCRNPDG AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY MGNLSKTRSG LTCSMWDKNM EDLHRHIFWE PDASKLTKNY CRNPDDDAHG PWCYTGNPLV PWDYCPISRC EGDTTPTIVN LDHPVISCAK TKQLRVVNGI PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR NKDLKDYEAW LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ GKVTLNESEL CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC AIPNRPGIFV RVAYYAKWIH KVILTYKL //