ID COLY_YERPE STANDARD; PRT; 312 AA. AC P17811; DT 01-AUG-1990 (REL. 15, CREATED) DT 01-AUG-1990 (REL. 15, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE COAGULASE/FIBRINOLYSIN PRECURSOR (EC 3.4.21.-) (PLASMINOGEN DE ACTIVATOR). GN PLA. OS YERSINIA PESTIS. OG PLASMID PKYP1, AND PLASMID PPCP1. OC PROKARYOTA; GRACILICUTES; SCOTOBACTERIA; FACULTATIVELY ANAEROBIC RODS; OC ENTEROBACTERIACEAE. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=EV76-6; PLASMID=PKYP1; RX MEDLINE; 89313306. RA MCDONOUGH K.A., FALKOW S.; RL MOL. MICROBIOL. 3:767-775(1989). RN [2] RP SEQUENCE FROM N.A. RC PLASMID=PPCP1; RX MEDLINE; 89212901. RA SODEINDE O.A., GOGUEN J.D.; RL INFECT. IMMUN. 57:1517-1523(1989). CC -!- FUNCTION: SEEMS TO PLAY AN ESSENTIAL ROLE IN PLAGUE TRANSMISSION CC BY MEDIATING FLEA BLOCKAGE IN A TEMPERATURE-DEPENDENT FASHION. CC FIBRINOLYTIC ACTIVITY PREVAILS AT 37 DEGREES CELSIUS WHEREAS CC COAGULASE EXPRESSION PREDOMINATES AT LOWER TEMPERATURES (<30 CC DEGREES CELSIUS). ACTIVATES PLASMINOGEN BY CLEAVING IT. CC -!- SUBUNIT: HOMOPENTAMER (POSSIBLE). CC -!- SUBCELLULAR LOCATION: OUTER MEMBRANE. CC -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY S18; ALSO KNOWN AS THE CC OMPTIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X15136; G48630; -. DR EMBL; M27820; G155525; ALT_SEQ. DR PIR; A30916; A30916. DR PIR; A42928; A42928. DR PIR; S06979; S06979. DR PROSITE; PS00834; OMPTIN_1. DR PROSITE; PS00835; OMPTIN_2. KW HYDROLASE; SERINE PROTEASE; OUTER MEMBRANE; SIGNAL; PLASMID. FT SIGNAL 1 20 POTENTIAL. FT CHAIN 21 312 COAGULASE/FIBRINOLYSIN. SQ SEQUENCE 312 AA; 34611 MW; 1EAFAAD1 CRC32; MKKSSIVATI ITILSGSANA ASSQLIPNIS PDSFTVAAST GMLSGKSHEM LYDAETGRKI SQLDWKIKNV AILKGDISWD PYSFLTLNAR GWTSLASGSG NMDDYDWMNE NQSEWTDHSS HPATNVNHAN EYDLNVKGWL LQDENYKAGI TAGYQETRFS WTATGGSYSY NNGAYTGNFP KGVRVIGYNQ RFSMPYIGLA GQYRINDFEL NALFKFSDWV RAHDNDEHYM RDLTFREKTS GSRYYGTVIN AGYYVTPNAK VFAEFTYSKY DEGKGGTQTI DKNSGDSVSI GGDAAGISNK NYTVTAGLQY RF //