ID REV$HIV21 STANDARD; PRT; 103 AA. AC P17754; DT 01-AUG-1990 (REL. 15, CREATED) DT 01-AUG-1990 (REL. 15, LAST SEQUENCE UPDATE) DT 01-NOV-1991 (REL. 20, LAST ANNOTATION UPDATE) DE REV PROTEIN (ANTI-REPRESSION TRANSACTIVATOR PROTEIN) (ART/TRS). OS HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 (ISOLATE D194) (HIV-2). OC VIRIDAE; SS-RNA ENVELOPED VIRUSES; POSITIVE-STRAND; RETROVIRIDAE; OC LENTIVIRINAE. RN [1] RP SEQUENCE FROM N.A. RC MEDLINE=89184631; RA KUEHNEL H., VON BRIESEN H., DIETRICH U., ADAMSKI M., MIX D., RA BIESERT L., KREUTZ R., IMMELMANN A., HENCO K., MEICHSNER C., RA ANDREESEN R., GELDERBLOM H., RUEBSAMEN-WAIGMANN H.; RL PROC. NATL. ACAD. SCI. U.S.A. 86:2383-2387(1989). RN [2] RP SEQUENCE FROM N.A. RC MEDLINE=91045094; RA KUEHNEL H., KREUTZ R., RUEBSAMEN-WAIGMANN H.; RL NUCLEIC ACIDS RES. 18:6142-6142(1990). CC -!- FUNCTION: REV APPEARS TO ACT POST-TRANSCRIPTIONALLY TO RELIEVE CC NEGATIVE REPRESSION OF GAG AND ENV PRODUCTION. CC -!- SUBCELLULAR LOCATION: NUCLEAR PROTEIN THAT ACCUMULATES IN THE CC NUCLEOLI. CC -!- REV IS A PHOSPHOPROTEIN WHOSE STATE OF PHOSPHORYLATION IS MEDIATED CC BY A SPECIFIC SERINE KINASE ACTIVITY PRESENT IN THE NUCLEUS. CC -!- THIS ISOLATE IS FROM A GAMBIAN CASE OF 'NEURO-AIDS'. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J04542; HIV2D194. DR EMBL; X52223; HIVD194. DR HIV; J04542; REV$2D194. DR PIR; S12158; S12158. KW TRANSCRIPTION REGULATION; AIDS; PHOSPHORYLATION; NUCLEAR PROTEIN. SQ SEQUENCE 103 AA; 11962 MW; 49327 CN; MRDRADEEGL QEKLRLIRLL HQINPYPHGQ GTASQRRNRR RRRRRQWFRL VALATKLHTI PDPPTDSPLD RAIQQLQGLT IQELPDPPTD LPESNSNQGL AET //